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- W2072552158 abstract "A surface sensitive second order nonlinear optical technique, sum frequency generation vibrational spectroscopy, was applied to study peptide orientation on polymer surfaces, supplemented by a linear vibrational spectroscopy, attenuated total reflectance Fourier transform infrared spectroscopy. Using the antimicrobial peptide Cecropin P1 as a model system, we have quantitatively demonstrated that chemically immobilized peptides on polymers adopt a more ordered orientation than less tightly bound physically adsorbed peptides. These differences were also observed in different chemical environments, for example, air versus water. Although numerous studies have reported a direct correlation between the choice of immobilization method and the performance of an attached biological molecule, the lack of direct biomolecular structure and orientation data has made it difficult to elucidate the relationship between structure, orientation, and function at a surface. In this work, we directly studied the effect of chemical immobilization method on biomolecular orientation/ordering, an important step for future studies of biomolecular activity. The methods for orientation analysis described within are also of relevance to understanding biosensors, biocompatibility, marine-antifouling, membrane protein functions, and antimicrobial peptide activities." @default.
- W2072552158 created "2016-06-24" @default.
- W2072552158 creator A5024040295 @default.
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- W2072552158 creator A5043124433 @default.
- W2072552158 creator A5047855284 @default.
- W2072552158 creator A5054123780 @default.
- W2072552158 date "2009-12-04" @default.
- W2072552158 modified "2023-09-27" @default.
- W2072552158 title "Orientation Difference of Chemically Immobilized and Physically Adsorbed Biological Molecules on Polymers Detected at the Solid/Liquid Interfaces in Situ" @default.
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- W2072552158 doi "https://doi.org/10.1021/la903932w" @default.
- W2072552158 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2860701" @default.
- W2072552158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19961170" @default.
- W2072552158 hasPublicationYear "2009" @default.
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