Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072572854> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2072572854 endingPage "3635" @default.
- W2072572854 startingPage "3633" @default.
- W2072572854 abstract "Induction with the use of interleukin-2 receptor monoclonal antibodies may avoid many of the adverse events associated with polyclonal antibodies and significantly impact on rejection-free long-term survival in orthotopic liver transplantation (OLTx). We describe our experience with the use of basiliximab induction therapy in adult OLTx recipients on tacrolimus-based immunosuppression. Forty-six consecutive deceased donor primary OLTx were analyzed. All patients received standard doses of basiliximab, tacrolimus, and steroids. Mycophenolate mofetil was also used as indicated. The mean follow-up period was 17.9 months. Forty-three patients remained rejection-free during follow-up. The actuarial patient and graft survival rate at 2 years was 93%. The rate of histology-proven hepatitis C virus (HCV) recurrence was 24%, with two progressing to severe cholestatic recurrent HCV. None of the study patients developed (cytomegalovirus (CMV) infection or posttransplant lymphoproliferative disease (PTLD). Results were compared to a historical group of 46 OLTx recipients on tacrolimus-based immunosuppression without basiliximab induction. The historical group had a rejection rate of 34% with lower patient and graft survival rates of 71.74% and 69.5%, respectively, at 24 months as well as a higher histological HCV recurrence rate of 77% (17/22), with three patients progressing to graft failure within 2 years. CMV infection and disease developed in 4.5% of the patients. Although PTLD was not observed, three recipients with hepatocellular carcinoma (HCC) developed and died of metastatic HCC. Induction with basiliximab in combination with tacrolimus-based immunosuppressive regimen reduces the incidence of rejection and improves rejection-free survival rate after OLTx without increasing the incidence of CMV, PTLD, or HCV recurrence." @default.
- W2072572854 created "2016-06-24" @default.
- W2072572854 creator A5004591830 @default.
- W2072572854 creator A5007942142 @default.
- W2072572854 creator A5009535008 @default.
- W2072572854 creator A5025075253 @default.
- W2072572854 creator A5030290785 @default.
- W2072572854 creator A5078254820 @default.
- W2072572854 date "2006-12-01" @default.
- W2072572854 modified "2023-10-16" @default.
- W2072572854 title "Basiliximab Induction in Adult Liver Transplant Recipients With 93% Rejection-Free Patient and Graft Survival at 24 Months" @default.
- W2072572854 cites W1985137297 @default.
- W2072572854 cites W1996365364 @default.
- W2072572854 cites W2018801671 @default.
- W2072572854 cites W2076451571 @default.
- W2072572854 cites W2089268585 @default.
- W2072572854 cites W2118440713 @default.
- W2072572854 cites W2123720448 @default.
- W2072572854 cites W2155510029 @default.
- W2072572854 doi "https://doi.org/10.1016/j.transproceed.2006.10.110" @default.
- W2072572854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17175352" @default.
- W2072572854 hasPublicationYear "2006" @default.
- W2072572854 type Work @default.
- W2072572854 sameAs 2072572854 @default.
- W2072572854 citedByCount "25" @default.
- W2072572854 countsByYear W20725728542012 @default.
- W2072572854 countsByYear W20725728542013 @default.
- W2072572854 countsByYear W20725728542014 @default.
- W2072572854 countsByYear W20725728542015 @default.
- W2072572854 countsByYear W20725728542016 @default.
- W2072572854 countsByYear W20725728542017 @default.
- W2072572854 countsByYear W20725728542019 @default.
- W2072572854 countsByYear W20725728542020 @default.
- W2072572854 countsByYear W20725728542022 @default.
- W2072572854 countsByYear W20725728542023 @default.
- W2072572854 crossrefType "journal-article" @default.
- W2072572854 hasAuthorship W2072572854A5004591830 @default.
- W2072572854 hasAuthorship W2072572854A5007942142 @default.
- W2072572854 hasAuthorship W2072572854A5009535008 @default.
- W2072572854 hasAuthorship W2072572854A5025075253 @default.
- W2072572854 hasAuthorship W2072572854A5030290785 @default.
- W2072572854 hasAuthorship W2072572854A5078254820 @default.
- W2072572854 hasConcept C126322002 @default.
- W2072572854 hasConcept C141071460 @default.
- W2072572854 hasConcept C2778019345 @default.
- W2072572854 hasConcept C2779609443 @default.
- W2072572854 hasConcept C2780252810 @default.
- W2072572854 hasConcept C2781307858 @default.
- W2072572854 hasConcept C2909675724 @default.
- W2072572854 hasConcept C2911091166 @default.
- W2072572854 hasConcept C71924100 @default.
- W2072572854 hasConcept C90924648 @default.
- W2072572854 hasConceptScore W2072572854C126322002 @default.
- W2072572854 hasConceptScore W2072572854C141071460 @default.
- W2072572854 hasConceptScore W2072572854C2778019345 @default.
- W2072572854 hasConceptScore W2072572854C2779609443 @default.
- W2072572854 hasConceptScore W2072572854C2780252810 @default.
- W2072572854 hasConceptScore W2072572854C2781307858 @default.
- W2072572854 hasConceptScore W2072572854C2909675724 @default.
- W2072572854 hasConceptScore W2072572854C2911091166 @default.
- W2072572854 hasConceptScore W2072572854C71924100 @default.
- W2072572854 hasConceptScore W2072572854C90924648 @default.
- W2072572854 hasIssue "10" @default.
- W2072572854 hasLocation W20725728541 @default.
- W2072572854 hasLocation W20725728542 @default.
- W2072572854 hasOpenAccess W2072572854 @default.
- W2072572854 hasPrimaryLocation W20725728541 @default.
- W2072572854 hasRelatedWork W1705018154 @default.
- W2072572854 hasRelatedWork W1996102154 @default.
- W2072572854 hasRelatedWork W2003051278 @default.
- W2072572854 hasRelatedWork W2036845344 @default.
- W2072572854 hasRelatedWork W2039925961 @default.
- W2072572854 hasRelatedWork W2083124691 @default.
- W2072572854 hasRelatedWork W2472485432 @default.
- W2072572854 hasRelatedWork W3002064010 @default.
- W2072572854 hasRelatedWork W4254351441 @default.
- W2072572854 hasRelatedWork W4309030526 @default.
- W2072572854 hasVolume "38" @default.
- W2072572854 isParatext "false" @default.
- W2072572854 isRetracted "false" @default.
- W2072572854 magId "2072572854" @default.
- W2072572854 workType "article" @default.