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• W2072574134 abstract "You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology & Natural History1 Apr 2014PD21-06 THE ROLE OF AGE AND PROSTATE CANCER ANXIETY ON URINARY SYMPTOMS IN MEN ON ACTIVE SURVEILLANCE David Hatcher, Chi-Hsiung Wang, Kristian R. Novakovic, Charles Brendler, Michael McGuire, David Victorson, and Brian T. Helfand David HatcherDavid Hatcher More articles by this author , Chi-Hsiung WangChi-Hsiung Wang More articles by this author , Kristian R. NovakovicKristian R. Novakovic More articles by this author , Charles BrendlerCharles Brendler More articles by this author , Michael McGuireMichael McGuire More articles by this author , David VictorsonDavid Victorson More articles by this author , and Brian T. HelfandBrian T. Helfand More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1683AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives Active surveillance (AS) can be associated with anxiety related to the intentional delay of definitive prostate cancer (PC) treatment. We investigated the potential relationship between anxiety and lower urinary tract symptoms (LUTS) in a cohort of men enrolled in AS. Methods A prospective cohort study was conducted of men on AS. Men underwent repeat (confirmatory) biopsy within 6 months of enrollment. All men completed the Memorial Anxiety Score for PC (MAX-PC) and AUA Symptom Index (AUA-SI) questionnaires at enrollment and repeat biopsy. Comparisons were made of MAX-PC and AUA-SI scores based on time until repeat biopsy (<3 months versus >3 months). Some analyses involved comparisons with the AUA-SI irritative (Q2,4,7) and obstructive (Q1,3,5,6) subdomains. Regression analysis was used to examine the impact of age and anxiety on LUTS. Results 195 men (mean age 66.5 years) met inclusion criteria. Mean prostate volume was 47g, and mean PSA was 5.2ng/ml. When comparing the group of men with a scheduled prostate biopsy within 3 months versus those with a more distant biopsy, the MAX-PC total score and two of its subscores (prostate cancer anxiety and PSA anxiety) were found to be statistically higher (p=0.03, p=0.007, and p=0.06, respectively), indicating an increased level of anxiety in the <3 month group. On multiple regression analysis, both age (p=0.045) and MAX-PC total score (p=0.064) were predictive of higher AUA-SI scores, accounting for 11% of its variability (r2=11.4%). When performed on the AUA-SI subcategories, age and MAX-PC total score were predictive of irritative symptoms (p=0.010 and p=0.032, respectively), but not obstructive symptoms and accounted for 15% of irritative score variability (r2=15.3%). Conclusions The time from prostate biopsy was inversely related to anxiety level, but not LUTS. Anxiety, specifically the MAX-PC score, as well as age, were predictive of higher AUA-SI scores and irritative symptoms. Anxiety can potentially be modified through stress reduction therapies, which may be of use for LUTS management in this population. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e607-e608 Advertisement Copyright & Permissions© 2014MetricsAuthor Information David Hatcher More articles by this author Chi-Hsiung Wang More articles by this author Kristian R. Novakovic More articles by this author Charles Brendler More articles by this author Michael McGuire More articles by this author David Victorson More articles by this author Brian T. Helfand More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2072574134 title "PD21-06 THE ROLE OF AGE AND PROSTATE CANCER ANXIETY ON URINARY SYMPTOMS IN MEN ON ACTIVE SURVEILLANCE" @default.
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