Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072579427> ?p ?o ?g. }
- W2072579427 endingPage "464" @default.
- W2072579427 startingPage "457" @default.
- W2072579427 abstract "Hepatic stellate cells (HSCs) have immunosuppressive abilities and may be responsible for the occurrence and development of hepatocellular carcinoma (HCC). However, the mechanisms through which HSCs affect T-cell-mediated immune responses remain unclear. The aim of this study was to elucidate these mechanisms. We examined the effect of HSCs on T-cell proliferation and apoptosis, regulatory T cells (Treg cells) and T-cell-mediated cytotoxicity using mixed leukocyte reactions (MLRs). Furthermore, we examined the cytokines present in the supernatant and the effect of this supernatant on the proliferation and migration of cancer cells. Finally, we examined the effect of HSCs on HCC cells in vivo. We found that activated HSCs induced T-cell hyporesponsiveness, accelerated activated T-cell apoptosis, increased the number of Treg cells and inhibited T-cell-mediated cytotoxicity. HSCs also enhanced the expression of some cytokines and promoted the proliferation and migration of cancer cells. Furthermore, activated HSCs were able to induce HCC proliferation and Treg cells expansion in vivo. Activated HSCs may induce T cell anergy, thereby facilitating the immunologic escape of HCC cells." @default.
- W2072579427 created "2016-06-24" @default.
- W2072579427 creator A5022196998 @default.
- W2072579427 creator A5034615558 @default.
- W2072579427 creator A5059352135 @default.
- W2072579427 creator A5060006875 @default.
- W2072579427 creator A5065532385 @default.
- W2072579427 creator A5068388793 @default.
- W2072579427 creator A5088304835 @default.
- W2072579427 date "2012-05-24" @default.
- W2072579427 modified "2023-09-29" @default.
- W2072579427 title "The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma" @default.
- W2072579427 cites W1500676217 @default.
- W2072579427 cites W1536476892 @default.
- W2072579427 cites W1963564133 @default.
- W2072579427 cites W1971890973 @default.
- W2072579427 cites W1978023299 @default.
- W2072579427 cites W1981725699 @default.
- W2072579427 cites W1983195062 @default.
- W2072579427 cites W1985569603 @default.
- W2072579427 cites W1988505877 @default.
- W2072579427 cites W1996660822 @default.
- W2072579427 cites W2000113015 @default.
- W2072579427 cites W2008528559 @default.
- W2072579427 cites W2010830736 @default.
- W2072579427 cites W2020478778 @default.
- W2072579427 cites W2023466335 @default.
- W2072579427 cites W2040617968 @default.
- W2072579427 cites W2047717009 @default.
- W2072579427 cites W2072380594 @default.
- W2072579427 cites W2073716326 @default.
- W2072579427 cites W2083142606 @default.
- W2072579427 cites W2083672604 @default.
- W2072579427 cites W2097750522 @default.
- W2072579427 cites W2102035695 @default.
- W2072579427 cites W2103944130 @default.
- W2072579427 cites W2104193042 @default.
- W2072579427 cites W2111288662 @default.
- W2072579427 cites W2111436737 @default.
- W2072579427 cites W2146942249 @default.
- W2072579427 cites W2150543192 @default.
- W2072579427 cites W2158129157 @default.
- W2072579427 cites W2323637528 @default.
- W2072579427 cites W2336449142 @default.
- W2072579427 doi "https://doi.org/10.3892/ijo.2012.1497" @default.
- W2072579427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3582803" @default.
- W2072579427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22641338" @default.
- W2072579427 hasPublicationYear "2012" @default.
- W2072579427 type Work @default.
- W2072579427 sameAs 2072579427 @default.
- W2072579427 citedByCount "39" @default.
- W2072579427 countsByYear W20725794272013 @default.
- W2072579427 countsByYear W20725794272014 @default.
- W2072579427 countsByYear W20725794272015 @default.
- W2072579427 countsByYear W20725794272016 @default.
- W2072579427 countsByYear W20725794272017 @default.
- W2072579427 countsByYear W20725794272019 @default.
- W2072579427 countsByYear W20725794272020 @default.
- W2072579427 countsByYear W20725794272021 @default.
- W2072579427 countsByYear W20725794272022 @default.
- W2072579427 countsByYear W20725794272023 @default.
- W2072579427 crossrefType "journal-article" @default.
- W2072579427 hasAuthorship W2072579427A5022196998 @default.
- W2072579427 hasAuthorship W2072579427A5034615558 @default.
- W2072579427 hasAuthorship W2072579427A5059352135 @default.
- W2072579427 hasAuthorship W2072579427A5060006875 @default.
- W2072579427 hasAuthorship W2072579427A5065532385 @default.
- W2072579427 hasAuthorship W2072579427A5068388793 @default.
- W2072579427 hasAuthorship W2072579427A5088304835 @default.
- W2072579427 hasBestOaLocation W20725794271 @default.
- W2072579427 hasConcept C109316439 @default.
- W2072579427 hasConcept C121608353 @default.
- W2072579427 hasConcept C134018914 @default.
- W2072579427 hasConcept C1491633281 @default.
- W2072579427 hasConcept C176891718 @default.
- W2072579427 hasConcept C190283241 @default.
- W2072579427 hasConcept C202751555 @default.
- W2072579427 hasConcept C203014093 @default.
- W2072579427 hasConcept C2776090121 @default.
- W2072579427 hasConcept C2781018059 @default.
- W2072579427 hasConcept C29537977 @default.
- W2072579427 hasConcept C502942594 @default.
- W2072579427 hasConcept C54355233 @default.
- W2072579427 hasConcept C55493867 @default.
- W2072579427 hasConcept C62112901 @default.
- W2072579427 hasConcept C86803240 @default.
- W2072579427 hasConcept C8891405 @default.
- W2072579427 hasConcept C95444343 @default.
- W2072579427 hasConcept C96232424 @default.
- W2072579427 hasConceptScore W2072579427C109316439 @default.
- W2072579427 hasConceptScore W2072579427C121608353 @default.
- W2072579427 hasConceptScore W2072579427C134018914 @default.
- W2072579427 hasConceptScore W2072579427C1491633281 @default.
- W2072579427 hasConceptScore W2072579427C176891718 @default.
- W2072579427 hasConceptScore W2072579427C190283241 @default.
- W2072579427 hasConceptScore W2072579427C202751555 @default.
- W2072579427 hasConceptScore W2072579427C203014093 @default.
- W2072579427 hasConceptScore W2072579427C2776090121 @default.