FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072581169> ?p ?o ?g. }

• W2072581169 endingPage "491" @default.
• W2072581169 startingPage "485" @default.
• W2072581169 abstract "We determined whether hepatic stimulator substance shares its mitogenic specificity for hepatocytes with nonparenchymal epithelial cells in the hepatocyte lineage. Cell lines designated HTC (derived from a rat hepatoma known to respond to hepatic stimulator substance) and FNRL, K-16 and K-22 (derived from rat liver nonparenchymal epithelial cells) were used. After exposure to hepatic stimulator substance, [3H]-thymidine incorporation into DNA was significantly increased (p < 0.001) in HTC, FNRL and K-16 cells, but not in K-22 cells. Fluorescence-activated cell sorting demonstrated that the mitogenic response to hepatic stimulator substance was associated with a greater proportion of cells entering the S phase. Epidermal growth factor, alone or in combination with hepatic stimulator substance, had no significant mitogenic effect on FNRL cells, but exposure of these cells to transforming growth factor-β1 inhibited [3H]-thymidine incorporation into DNA and reduced the proportion of cells in the S and G2/M phases. Simultaneous exposure of FNRL cells to hepatic stimulator substance and transforming growth factor-β1 abrogated the inhibitory effect of transforming growth factor-β1. Comparison of butyrate-synchronized HTC cells with hepatic stimulator substance–treated HTC cells showed that S-phase progression in these conditions was different, with no intervening cell cycle arrest after treatment with hepatic stimulator substance. Mitogenic stimulation of FNRL and K-16 cells with the liver-specific growth factor hepatic stimulator substance suggests that these cells are of hepatocyte lineage. These results strengthen the evidence for a possible link between hepatocytes and nonparenchymal liver epithelial cells during liver biogenesis and differentiation. (Hepatology 1992;15:485–491)." @default.
• W2072581169 created "2016-06-24" @default.
• W2072581169 creator A5061056387 @default.
• W2072581169 creator A5085377244 @default.
• W2072581169 creator A5087066859 @default.
• W2072581169 date "1992-03-01" @default.
• W2072581169 modified "2023-10-15" @default.
• W2072581169 title "Mitogenic effects of hepatic stimulator substance on cultured nonparenchymal liver epithelial cells" @default.
• W2072581169 cites W1490154674 @default.
• W2072581169 cites W1561559762 @default.
• W2072581169 cites W1563645938 @default.
• W2072581169 cites W1823130351 @default.
• W2072581169 cites W1851773867 @default.
• W2072581169 cites W1963565705 @default.
• W2072581169 cites W1976794059 @default.
• W2072581169 cites W1977779461 @default.
• W2072581169 cites W1987507774 @default.
• W2072581169 cites W1996053339 @default.
• W2072581169 cites W1996497126 @default.
• W2072581169 cites W2001104440 @default.
• W2072581169 cites W2005782838 @default.
• W2072581169 cites W2014669590 @default.
• W2072581169 cites W2016150537 @default.
• W2072581169 cites W2032941942 @default.
• W2072581169 cites W2035084993 @default.
• W2072581169 cites W2051172626 @default.
• W2072581169 cites W2052674146 @default.
• W2072581169 cites W2079263067 @default.
• W2072581169 cites W2084508917 @default.
• W2072581169 cites W2086781527 @default.
• W2072581169 cites W2091455117 @default.
• W2072581169 cites W2141617559 @default.
• W2072581169 cites W2147727142 @default.
• W2072581169 cites W2150662486 @default.
• W2072581169 cites W2491582705 @default.
• W2072581169 cites W4294216491 @default.
• W2072581169 doi "https://doi.org/10.1002/hep.1840150322" @default.
• W2072581169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1544631" @default.
• W2072581169 hasPublicationYear "1992" @default.
• W2072581169 type Work @default.
• W2072581169 sameAs 2072581169 @default.
• W2072581169 citedByCount "33" @default.
• W2072581169 countsByYear W20725811692012 @default.
• W2072581169 countsByYear W20725811692015 @default.
• W2072581169 countsByYear W20725811692019 @default.
• W2072581169 crossrefType "journal-article" @default.
• W2072581169 hasAuthorship W2072581169A5061056387 @default.
• W2072581169 hasAuthorship W2072581169A5085377244 @default.
• W2072581169 hasAuthorship W2072581169A5087066859 @default.
• W2072581169 hasConcept C126322002 @default.
• W2072581169 hasConcept C134018914 @default.
• W2072581169 hasConcept C1491633281 @default.
• W2072581169 hasConcept C170493617 @default.
• W2072581169 hasConcept C176891718 @default.
• W2072581169 hasConcept C202751555 @default.
• W2072581169 hasConcept C24998067 @default.
• W2072581169 hasConcept C2775960820 @default.
• W2072581169 hasConcept C2776200302 @default.
• W2072581169 hasConcept C2776362946 @default.
• W2072581169 hasConcept C2776996007 @default.
• W2072581169 hasConcept C2777108182 @default.
• W2072581169 hasConcept C2778260397 @default.
• W2072581169 hasConcept C29537977 @default.
• W2072581169 hasConcept C54355233 @default.
• W2072581169 hasConcept C55493867 @default.
• W2072581169 hasConcept C62112901 @default.
• W2072581169 hasConcept C64241487 @default.
• W2072581169 hasConcept C71924100 @default.
• W2072581169 hasConcept C81885089 @default.
• W2072581169 hasConcept C86803240 @default.
• W2072581169 hasConceptScore W2072581169C126322002 @default.
• W2072581169 hasConceptScore W2072581169C134018914 @default.
• W2072581169 hasConceptScore W2072581169C1491633281 @default.
• W2072581169 hasConceptScore W2072581169C170493617 @default.
• W2072581169 hasConceptScore W2072581169C176891718 @default.
• W2072581169 hasConceptScore W2072581169C202751555 @default.
• W2072581169 hasConceptScore W2072581169C24998067 @default.
• W2072581169 hasConceptScore W2072581169C2775960820 @default.
• W2072581169 hasConceptScore W2072581169C2776200302 @default.
• W2072581169 hasConceptScore W2072581169C2776362946 @default.
• W2072581169 hasConceptScore W2072581169C2776996007 @default.
• W2072581169 hasConceptScore W2072581169C2777108182 @default.
• W2072581169 hasConceptScore W2072581169C2778260397 @default.
• W2072581169 hasConceptScore W2072581169C29537977 @default.
• W2072581169 hasConceptScore W2072581169C54355233 @default.
• W2072581169 hasConceptScore W2072581169C55493867 @default.
• W2072581169 hasConceptScore W2072581169C62112901 @default.
• W2072581169 hasConceptScore W2072581169C64241487 @default.
• W2072581169 hasConceptScore W2072581169C71924100 @default.
• W2072581169 hasConceptScore W2072581169C81885089 @default.
• W2072581169 hasConceptScore W2072581169C86803240 @default.
• W2072581169 hasIssue "3" @default.
• W2072581169 hasLocation W20725811691 @default.
• W2072581169 hasLocation W20725811692 @default.
• W2072581169 hasOpenAccess W2072581169 @default.
• W2072581169 hasPrimaryLocation W20725811691 @default.
• W2072581169 hasRelatedWork W1567962285 @default.
• W2072581169 hasRelatedWork W1812173233 @default.

• next