Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072587315> ?p ?o ?g. }
- W2072587315 endingPage "187" @default.
- W2072587315 startingPage "179" @default.
- W2072587315 abstract "Liver transplantation (LT) is the best curative treatment for early hepatocellular carcinoma (HCC) in patients with cirrhosis. However, the current shortage of organs causes prolonged waiting times and poorer intention-to-treat (ITT) survival (i.e., after listing) owing to tumor progression and dropout. Portal hypertension (PH) is a recognized risk factor of HCC development in patients with cirrhosis and its recurrence after resection. The aim of this study was to evaluate the potential impact of PHT on the results of LT on an ITT basis. Patients with cirrhosis listed for LT for HCC were included and their outcomes after listing were compared according to the presence or absence of PH defined as presence of esophageal varices or ascites or low platelet count and splenomegaly. Among 243 consecutively listed patients, 70% were affected by PH, which was associated with a significantly higher risk of tumor progression (38% vs. 22%; P = 0.017) and a higher risk of dropout (22% vs. 8%; P = 0.01). Transarterial chemoembolization (TACE) was similarly applied to the two groups (60% vs. 67%; P = 0.325). An absence of TACE was the only other independent risk factor of dropout owing to tumor progression. Under an ITT analysis, PH reduced overall survival (OS), but there was no difference in OS and time to recurrence post-LT. The only pathological feature that could potentially explain this observation was the lower complete response to TACE in the PHT group (12% vs. 36%; P = 0.001).PH should be regarded as a major risk factor of dropout owing to tumor progression and should be taken into consideration when managing patients with HCC who are waiting for LT." @default.
- W2072587315 created "2016-06-24" @default.
- W2072587315 creator A5012325306 @default.
- W2072587315 creator A5014799768 @default.
- W2072587315 creator A5025554009 @default.
- W2072587315 creator A5031110405 @default.
- W2072587315 creator A5035655204 @default.
- W2072587315 creator A5046520953 @default.
- W2072587315 creator A5059508363 @default.
- W2072587315 creator A5070118413 @default.
- W2072587315 creator A5078766753 @default.
- W2072587315 creator A5079979267 @default.
- W2072587315 creator A5085489573 @default.
- W2072587315 date "2015-05-20" @default.
- W2072587315 modified "2023-10-18" @default.
- W2072587315 title "Impact of clinically evident portal hypertension on the course of hepatocellular carcinoma in patients listed for liver transplantation" @default.
- W2072587315 cites W1483808757 @default.
- W2072587315 cites W1964051982 @default.
- W2072587315 cites W1975981472 @default.
- W2072587315 cites W1977508103 @default.
- W2072587315 cites W1986826277 @default.
- W2072587315 cites W1992945715 @default.
- W2072587315 cites W1994613334 @default.
- W2072587315 cites W2001538016 @default.
- W2072587315 cites W2005464314 @default.
- W2072587315 cites W2006053115 @default.
- W2072587315 cites W2008423320 @default.
- W2072587315 cites W2009378591 @default.
- W2072587315 cites W2009671859 @default.
- W2072587315 cites W2019272767 @default.
- W2072587315 cites W2019832083 @default.
- W2072587315 cites W2044457468 @default.
- W2072587315 cites W2060050131 @default.
- W2072587315 cites W2065287858 @default.
- W2072587315 cites W2073377243 @default.
- W2072587315 cites W2076893603 @default.
- W2072587315 cites W2078434332 @default.
- W2072587315 cites W2080475565 @default.
- W2072587315 cites W2091600198 @default.
- W2072587315 cites W2093895772 @default.
- W2072587315 cites W2097407064 @default.
- W2072587315 cites W2101099470 @default.
- W2072587315 cites W2132711541 @default.
- W2072587315 cites W2147672103 @default.
- W2072587315 cites W2149727669 @default.
- W2072587315 cites W2162226128 @default.
- W2072587315 cites W2165142212 @default.
- W2072587315 cites W2315027248 @default.
- W2072587315 cites W2328641507 @default.
- W2072587315 cites W4245784696 @default.
- W2072587315 doi "https://doi.org/10.1002/hep.27864" @default.
- W2072587315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25914217" @default.
- W2072587315 hasPublicationYear "2015" @default.
- W2072587315 type Work @default.
- W2072587315 sameAs 2072587315 @default.
- W2072587315 citedByCount "31" @default.
- W2072587315 countsByYear W20725873152015 @default.
- W2072587315 countsByYear W20725873152016 @default.
- W2072587315 countsByYear W20725873152017 @default.
- W2072587315 countsByYear W20725873152018 @default.
- W2072587315 countsByYear W20725873152019 @default.
- W2072587315 countsByYear W20725873152020 @default.
- W2072587315 countsByYear W20725873152021 @default.
- W2072587315 countsByYear W20725873152022 @default.
- W2072587315 countsByYear W20725873152023 @default.
- W2072587315 crossrefType "journal-article" @default.
- W2072587315 hasAuthorship W2072587315A5012325306 @default.
- W2072587315 hasAuthorship W2072587315A5014799768 @default.
- W2072587315 hasAuthorship W2072587315A5025554009 @default.
- W2072587315 hasAuthorship W2072587315A5031110405 @default.
- W2072587315 hasAuthorship W2072587315A5035655204 @default.
- W2072587315 hasAuthorship W2072587315A5046520953 @default.
- W2072587315 hasAuthorship W2072587315A5059508363 @default.
- W2072587315 hasAuthorship W2072587315A5070118413 @default.
- W2072587315 hasAuthorship W2072587315A5078766753 @default.
- W2072587315 hasAuthorship W2072587315A5079979267 @default.
- W2072587315 hasAuthorship W2072587315A5085489573 @default.
- W2072587315 hasConcept C121608353 @default.
- W2072587315 hasConcept C126322002 @default.
- W2072587315 hasConcept C2777214474 @default.
- W2072587315 hasConcept C2777595160 @default.
- W2072587315 hasConcept C2778012290 @default.
- W2072587315 hasConcept C2778019345 @default.
- W2072587315 hasConcept C2778808290 @default.
- W2072587315 hasConcept C2779256057 @default.
- W2072587315 hasConcept C2779609443 @default.
- W2072587315 hasConcept C2780496750 @default.
- W2072587315 hasConcept C2911091166 @default.
- W2072587315 hasConcept C50440223 @default.
- W2072587315 hasConcept C71924100 @default.
- W2072587315 hasConcept C90924648 @default.
- W2072587315 hasConceptScore W2072587315C121608353 @default.
- W2072587315 hasConceptScore W2072587315C126322002 @default.
- W2072587315 hasConceptScore W2072587315C2777214474 @default.
- W2072587315 hasConceptScore W2072587315C2777595160 @default.
- W2072587315 hasConceptScore W2072587315C2778012290 @default.
- W2072587315 hasConceptScore W2072587315C2778019345 @default.
- W2072587315 hasConceptScore W2072587315C2778808290 @default.