Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072592153> ?p ?o ?g. }
- W2072592153 abstract "In vitro tests were performed to understand the effects of topical vehicles on the permeability of ketoprofen through artificial lipid barriers and heat-separated human epidermis consisting of stratum corneum and viable epidermis. Ketoprofen was selected as the model penetrant. Human epidermis and artificial membranes made from several mixtures of free fatty acids, cholesterol, cholesteryl ester, ceramides, and triglycerides were used as permeation matrices in untreated conditions and after pretreatment with petrolatum, wool alcohols ointment, or triglycerides. Apparent permeability and diffusion coefficients as well as the solubility of the drug in the artificial lipid matrices were ascertained. The solubilities of drugs and vehicle components that depend on the composition of the lipid matrix predominantly control the permeability of the barrier. Ceramides and cholesterol reduce the permeability and solubility, whereas triglycerides have the opposite effect. The vehicle effects in artificial membranes correspond to those in epidermis observed with samples pretreated with the aforementioned bases. The logarithms of the permeabilities of untreated and pretreated lipid mixtures 3, 4, and 5 are very well correlated with those of the permeabilities of heat-separated epidermis (r > = 0.9868). The artificial mixture containing all five lipids mentioned gives the best approximation to human epidermis. This result indicates comparable vehicle effects although the composition of the artificial mixture was adapted only in a simplified manner to the horny layer lipid phase. This lipid matrix or similar mixtures, therefore, are convenient tools for investigation into the effects of dermatological vehicles." @default.
- W2072592153 created "2016-06-24" @default.
- W2072592153 creator A5007553005 @default.
- W2072592153 creator A5018546214 @default.
- W2072592153 creator A5058590225 @default.
- W2072592153 date "2003-07-01" @default.
- W2072592153 modified "2023-10-14" @default.
- W2072592153 title "Comparison of effects of different ointment bases on the penetration of ketoprofen through heat-separated human epidermis and artificial lipid barriers" @default.
- W2072592153 cites W14432301 @default.
- W2072592153 cites W1561210178 @default.
- W2072592153 cites W1591789463 @default.
- W2072592153 cites W1965723285 @default.
- W2072592153 cites W1971726629 @default.
- W2072592153 cites W1993076102 @default.
- W2072592153 cites W1999543917 @default.
- W2072592153 cites W2000474048 @default.
- W2072592153 cites W2000574141 @default.
- W2072592153 cites W2003955457 @default.
- W2072592153 cites W2016954164 @default.
- W2072592153 cites W2019683263 @default.
- W2072592153 cites W2020369275 @default.
- W2072592153 cites W2021112387 @default.
- W2072592153 cites W2025345260 @default.
- W2072592153 cites W2040342112 @default.
- W2072592153 cites W2045845920 @default.
- W2072592153 cites W2050426841 @default.
- W2072592153 cites W2067653346 @default.
- W2072592153 cites W2073585288 @default.
- W2072592153 cites W2075327410 @default.
- W2072592153 cites W2077083659 @default.
- W2072592153 cites W2078936639 @default.
- W2072592153 cites W2079214615 @default.
- W2072592153 cites W2087806279 @default.
- W2072592153 cites W2088777382 @default.
- W2072592153 cites W2091247610 @default.
- W2072592153 cites W2095393201 @default.
- W2072592153 cites W2101453828 @default.
- W2072592153 cites W2108767240 @default.
- W2072592153 cites W2124050936 @default.
- W2072592153 cites W2141331305 @default.
- W2072592153 cites W2151702186 @default.
- W2072592153 cites W2321278656 @default.
- W2072592153 cites W2328407198 @default.
- W2072592153 cites W2346607550 @default.
- W2072592153 cites W2461979478 @default.
- W2072592153 cites W4205498083 @default.
- W2072592153 doi "https://doi.org/10.1002/jps.10398" @default.
- W2072592153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12820144" @default.
- W2072592153 hasPublicationYear "2003" @default.
- W2072592153 type Work @default.
- W2072592153 sameAs 2072592153 @default.
- W2072592153 citedByCount "18" @default.
- W2072592153 countsByYear W20725921532013 @default.
- W2072592153 countsByYear W20725921532015 @default.
- W2072592153 countsByYear W20725921532017 @default.
- W2072592153 countsByYear W20725921532018 @default.
- W2072592153 crossrefType "journal-article" @default.
- W2072592153 hasAuthorship W2072592153A5007553005 @default.
- W2072592153 hasAuthorship W2072592153A5018546214 @default.
- W2072592153 hasAuthorship W2072592153A5058590225 @default.
- W2072592153 hasConcept C105702510 @default.
- W2072592153 hasConcept C120882062 @default.
- W2072592153 hasConcept C12554922 @default.
- W2072592153 hasConcept C127413603 @default.
- W2072592153 hasConcept C141071460 @default.
- W2072592153 hasConcept C142724271 @default.
- W2072592153 hasConcept C155574463 @default.
- W2072592153 hasConcept C175933922 @default.
- W2072592153 hasConcept C178790620 @default.
- W2072592153 hasConcept C185154212 @default.
- W2072592153 hasConcept C185592680 @default.
- W2072592153 hasConcept C2776458125 @default.
- W2072592153 hasConcept C2777459323 @default.
- W2072592153 hasConcept C2778370115 @default.
- W2072592153 hasConcept C2780744026 @default.
- W2072592153 hasConcept C39944091 @default.
- W2072592153 hasConcept C41625074 @default.
- W2072592153 hasConcept C42475967 @default.
- W2072592153 hasConcept C43617362 @default.
- W2072592153 hasConcept C50670333 @default.
- W2072592153 hasConcept C54355233 @default.
- W2072592153 hasConcept C55493867 @default.
- W2072592153 hasConcept C71924100 @default.
- W2072592153 hasConcept C80107235 @default.
- W2072592153 hasConcept C86803240 @default.
- W2072592153 hasConceptScore W2072592153C105702510 @default.
- W2072592153 hasConceptScore W2072592153C120882062 @default.
- W2072592153 hasConceptScore W2072592153C12554922 @default.
- W2072592153 hasConceptScore W2072592153C127413603 @default.
- W2072592153 hasConceptScore W2072592153C141071460 @default.
- W2072592153 hasConceptScore W2072592153C142724271 @default.
- W2072592153 hasConceptScore W2072592153C155574463 @default.
- W2072592153 hasConceptScore W2072592153C175933922 @default.
- W2072592153 hasConceptScore W2072592153C178790620 @default.
- W2072592153 hasConceptScore W2072592153C185154212 @default.
- W2072592153 hasConceptScore W2072592153C185592680 @default.
- W2072592153 hasConceptScore W2072592153C2776458125 @default.
- W2072592153 hasConceptScore W2072592153C2777459323 @default.
- W2072592153 hasConceptScore W2072592153C2778370115 @default.
- W2072592153 hasConceptScore W2072592153C2780744026 @default.