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• W2072603469 startingPage "440" @default.
• W2072603469 abstract "Eur J Clin Invest 2010; 40 (5): 440–450 Abstract Background Calorie Restriction (CR) research has expanded rapidly over the past few decades and CR remains the most highly reproducible, environmental intervention to improve health and extend lifespan in animal studies. Although many model organisms have consistently demonstrated positive responses to CR, it remains to be shown whether CR will extend lifespan in humans. Additionally, the current environment of excess caloric consumption and high incidence of overweight/obesity illustrate the improbable nature of the long-term adoption of a CR lifestyle by a significant proportion of the human population. Thus, the search for substances that can reproduce the beneficial physiologic responses of CR without a requisite calorie intake reduction, termed CR mimetics (CRMs), has gained momentum. Material and methods Recent articles describing health and lifespan results of CR in nonhuman primates and short-term human studies are discussed. Additional consideration is given to the rapidly expanding search for CRMs. Results The first results from a long-term, randomized, controlled CR study in nonhuman primates showing statistically significant benefits on longevity have now been reported. Additionally, positive results from short-term, randomized, controlled CR studies in humans are suggestive of potential health and longevity gains, while test of proposed CRMs (including rapamycin, resveratrol, 2-deoxyglucose and metformin) have shown both positive and mixed results in rodents. Conclusion Whether current positive results will translate into longevity gains for humans remains an open question. However, the apparent health benefits that have been observed with CR suggest that regardless of longevity gains, the promotion of healthy ageing and disease prevention may be attainable." @default.
• W2072603469 created "2016-06-24" @default.
• W2072603469 creator A5005935966 @default.
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• W2072603469 date "2010-05-01" @default.
• W2072603469 modified "2023-10-15" @default.
• W2072603469 title "Calorie restriction: what recent results suggest for the future of ageing research" @default.
• W2072603469 cites W1491750629 @default.
• W2072603469 cites W1513767024 @default.
• W2072603469 cites W1514533495 @default.
• W2072603469 cites W1522363204 @default.
• W2072603469 cites W1527539101 @default.
• W2072603469 cites W1583148430 @default.
• W2072603469 cites W1632132781 @default.
• W2072603469 cites W1794471252 @default.
• W2072603469 cites W1965414585 @default.
• W2072603469 cites W1965507724 @default.
• W2072603469 cites W1966132436 @default.
• W2072603469 cites W1969162136 @default.
• W2072603469 cites W1970937302 @default.
• W2072603469 cites W1972545707 @default.
• W2072603469 cites W1975648577 @default.
• W2072603469 cites W1978792924 @default.
• W2072603469 cites W1981409978 @default.
• W2072603469 cites W1985244614 @default.
• W2072603469 cites W1986905365 @default.
• W2072603469 cites W1987140385 @default.
• W2072603469 cites W1987738803 @default.
• W2072603469 cites W1987826934 @default.
• W2072603469 cites W1989993058 @default.
• W2072603469 cites W1991087616 @default.
• W2072603469 cites W1991096049 @default.
• W2072603469 cites W1991749464 @default.
• W2072603469 cites W1992657370 @default.
• W2072603469 cites W1995384855 @default.
• W2072603469 cites W1997145913 @default.
• W2072603469 cites W1997746720 @default.
• W2072603469 cites W2003982897 @default.
• W2072603469 cites W2006022142 @default.
• W2072603469 cites W2007711341 @default.
• W2072603469 cites W2007842741 @default.
• W2072603469 cites W2008675254 @default.
• W2072603469 cites W2009139592 @default.
• W2072603469 cites W2009332336 @default.
• W2072603469 cites W2013749723 @default.
• W2072603469 cites W2014399461 @default.
• W2072603469 cites W2014717126 @default.
• W2072603469 cites W2017277573 @default.
• W2072603469 cites W2018288123 @default.
• W2072603469 cites W2018951168 @default.
• W2072603469 cites W2020513326 @default.
• W2072603469 cites W2021493008 @default.
• W2072603469 cites W2024163691 @default.
• W2072603469 cites W2027423883 @default.
• W2072603469 cites W2030031350 @default.
• W2072603469 cites W2033599409 @default.
• W2072603469 cites W2034022260 @default.
• W2072603469 cites W2034278983 @default.
• W2072603469 cites W2034413186 @default.
• W2072603469 cites W2035376627 @default.
• W2072603469 cites W2037211598 @default.
• W2072603469 cites W2045201133 @default.
• W2072603469 cites W2048376025 @default.
• W2072603469 cites W2051762464 @default.
• W2072603469 cites W2059144648 @default.
• W2072603469 cites W2059465746 @default.
• W2072603469 cites W2060814375 @default.
• W2072603469 cites W2061091970 @default.
• W2072603469 cites W2061339974 @default.
• W2072603469 cites W2063186064 @default.
• W2072603469 cites W2064133996 @default.
• W2072603469 cites W2064773221 @default.
• W2072603469 cites W2067395327 @default.
• W2072603469 cites W2067805867 @default.
• W2072603469 cites W2071314267 @default.
• W2072603469 cites W2073151196 @default.
• W2072603469 cites W2073701988 @default.
• W2072603469 cites W2074037083 @default.
• W2072603469 cites W2077612844 @default.
• W2072603469 cites W2081467380 @default.
• W2072603469 cites W2082603625 @default.
• W2072603469 cites W2082900943 @default.
• W2072603469 cites W2084935123 @default.
• W2072603469 cites W2088381487 @default.
• W2072603469 cites W2088769174 @default.
• W2072603469 cites W2089022581 @default.
• W2072603469 cites W2091316238 @default.
• W2072603469 cites W2091424052 @default.
• W2072603469 cites W2092509345 @default.
• W2072603469 cites W2094720663 @default.
• W2072603469 cites W2098385754 @default.
• W2072603469 cites W2100332091 @default.
• W2072603469 cites W2100408829 @default.
• W2072603469 cites W2101659489 @default.
• W2072603469 cites W2102646072 @default.
• W2072603469 cites W2103416697 @default.
• W2072603469 cites W2103538220 @default.

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