Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072610097> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2072610097 abstract "Purpose: A challenge with cardiac cell therapy is determining the location of cells relative to infarct tissue. As cells are viable following 111In‐labeling, and first‐pass CTimaging can identify regions of myocardial infarction, we evaluated the feasibility of a SPECT/CT system to localize and track cells relative to infarcted myocardium in a canine model. Methods: To determine accuracy of SPECT/CT registration, images were acquired of capillary tubes filled with CT and SPECT contrast agents. Accuracy was measured by comparing locations of tube centroids in SPECT and CT. Ten canines underwent surgical ligation of the left‐anterior‐descending artery and endothelial progenitor cells labeled with 111In‐tropolone were transplanted endocardially or epicardially. SPECT/CT was performed on day of transplantation, 4, and 10 days post‐transplantation. For each imaging session first‐pass perfusion CT was performed to delineate the infarct zone. SPECT and first‐pass CTimages were fused and evaluated. Delayed‐enhanced MRI was performed to validate CT infarct localization. Contrast‐to‐noise ratios (CNR) were calculated for 111In‐SPECT images to evaluate cell detection. Results: Phantom SPECT/CT registration accuracy was approximately 1mm. The infarct zone was well delineated on first‐pass perfusion CT in all canines and correlated well with MRI findings. 111In signal was visualized within the infarct zone in all cases. Analysis of the CNRs suggests that cells can be followed for 11 effective half‐lives provided the location of the cells can be inferred by first‐pass CT.Conclusion: SPECT/[First‐Pass Perfusion CT] is an effective hybrid platform for the localization and tracking of stem cells in relation to infarct tissue." @default.
- W2072610097 created "2016-06-24" @default.
- W2072610097 creator A5002994406 @default.
- W2072610097 creator A5016431412 @default.
- W2072610097 creator A5017223923 @default.
- W2072610097 creator A5046544425 @default.
- W2072610097 creator A5064215872 @default.
- W2072610097 creator A5069709686 @default.
- W2072610097 creator A5070858953 @default.
- W2072610097 creator A5073062973 @default.
- W2072610097 creator A5079085218 @default.
- W2072610097 date "2010-07-01" @default.
- W2072610097 modified "2023-09-27" @default.
- W2072610097 title "Sci-Fri AM: Imaging - 09: Hybrid SPECT and First-Pass Perfusion CT: Application in Cell Localization" @default.
- W2072610097 doi "https://doi.org/10.1118/1.3476188" @default.
- W2072610097 hasPublicationYear "2010" @default.
- W2072610097 type Work @default.
- W2072610097 sameAs 2072610097 @default.
- W2072610097 citedByCount "0" @default.
- W2072610097 crossrefType "journal-article" @default.
- W2072610097 hasAuthorship W2072610097A5002994406 @default.
- W2072610097 hasAuthorship W2072610097A5016431412 @default.
- W2072610097 hasAuthorship W2072610097A5017223923 @default.
- W2072610097 hasAuthorship W2072610097A5046544425 @default.
- W2072610097 hasAuthorship W2072610097A5064215872 @default.
- W2072610097 hasAuthorship W2072610097A5069709686 @default.
- W2072610097 hasAuthorship W2072610097A5070858953 @default.
- W2072610097 hasAuthorship W2072610097A5073062973 @default.
- W2072610097 hasAuthorship W2072610097A5079085218 @default.
- W2072610097 hasConcept C104293457 @default.
- W2072610097 hasConcept C126322002 @default.
- W2072610097 hasConcept C126838900 @default.
- W2072610097 hasConcept C135691158 @default.
- W2072610097 hasConcept C146957229 @default.
- W2072610097 hasConcept C2911091166 @default.
- W2072610097 hasConcept C2984398910 @default.
- W2072610097 hasConcept C2989005 @default.
- W2072610097 hasConcept C71924100 @default.
- W2072610097 hasConceptScore W2072610097C104293457 @default.
- W2072610097 hasConceptScore W2072610097C126322002 @default.
- W2072610097 hasConceptScore W2072610097C126838900 @default.
- W2072610097 hasConceptScore W2072610097C135691158 @default.
- W2072610097 hasConceptScore W2072610097C146957229 @default.
- W2072610097 hasConceptScore W2072610097C2911091166 @default.
- W2072610097 hasConceptScore W2072610097C2984398910 @default.
- W2072610097 hasConceptScore W2072610097C2989005 @default.
- W2072610097 hasConceptScore W2072610097C71924100 @default.
- W2072610097 hasLocation W20726100971 @default.
- W2072610097 hasOpenAccess W2072610097 @default.
- W2072610097 hasPrimaryLocation W20726100971 @default.
- W2072610097 hasRelatedWork W109098852 @default.
- W2072610097 hasRelatedWork W1928305610 @default.
- W2072610097 hasRelatedWork W1968695068 @default.
- W2072610097 hasRelatedWork W1969033948 @default.
- W2072610097 hasRelatedWork W1985981600 @default.
- W2072610097 hasRelatedWork W2006162164 @default.
- W2072610097 hasRelatedWork W2014189875 @default.
- W2072610097 hasRelatedWork W2014261312 @default.
- W2072610097 hasRelatedWork W2020995830 @default.
- W2072610097 hasRelatedWork W2022617061 @default.
- W2072610097 hasRelatedWork W202828514 @default.
- W2072610097 hasRelatedWork W2349373555 @default.
- W2072610097 hasRelatedWork W2500294252 @default.
- W2072610097 hasRelatedWork W2518827006 @default.
- W2072610097 hasRelatedWork W2963765163 @default.
- W2072610097 hasRelatedWork W3118181316 @default.
- W2072610097 hasRelatedWork W3175915038 @default.
- W2072610097 hasRelatedWork W2280485209 @default.
- W2072610097 hasRelatedWork W2285898120 @default.
- W2072610097 hasRelatedWork W2977600002 @default.
- W2072610097 isParatext "false" @default.
- W2072610097 isRetracted "false" @default.
- W2072610097 magId "2072610097" @default.
- W2072610097 workType "article" @default.