Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072612850> ?p ?o ?g. }
- W2072612850 endingPage "429" @default.
- W2072612850 startingPage "411" @default.
- W2072612850 abstract "The use of second generation cationic liposomes to deliver cytotoxic drugs to solid tumors is a rational and promising therapeutic approach, given the natural affinity of cationic carrier molecules for the tumor microvasculature. Cationic liposomal therapeutics are effective in the treatment of cancers that are resistant to conventional chemotherapy and other treatment modalities. Researchers are now exploring novel ways to combine cationic nanosystems with other treatment approaches. For example, strategies for using cationic liposomes with hyperthermia or magnetic fields have been evaluated. Drug-loaded cationic liposomes have been documented to induce tumor vascular defects, alter vascular function and limit the growth of the primary tumors and metastasis. In this review, we discuss general features of the endothelium as a function of its tissue environment. We discuss the rationale for targeting tumor vessels over the tumor interstitial matrix, and for the development of second generation cationic lipids and liposomes for tumor vascular targeting. We evaluate the benefits of incorporating the polymer polyethylene-glycol (PEG) in conventional and cationic liposomes for nonspecific and relatively vascular-specific tumor targeting, respectively. Finally, we review preclinical and clinical investigations evaluating drug-loaded cationic liposomes in cancer treatment." @default.
- W2072612850 created "2016-06-24" @default.
- W2072612850 creator A5025024895 @default.
- W2072612850 creator A5081578689 @default.
- W2072612850 creator A5082036476 @default.
- W2072612850 creator A5085010424 @default.
- W2072612850 date "2009-02-01" @default.
- W2072612850 modified "2023-10-06" @default.
- W2072612850 title "Fighting Cancer: From the Bench to Bedside Using Second Generation Cationic Liposomal Therapeutics" @default.
- W2072612850 cites W1566407827 @default.
- W2072612850 cites W1572380591 @default.
- W2072612850 cites W1573413261 @default.
- W2072612850 cites W1906686114 @default.
- W2072612850 cites W1964935114 @default.
- W2072612850 cites W1968522189 @default.
- W2072612850 cites W1968968207 @default.
- W2072612850 cites W1971290197 @default.
- W2072612850 cites W1976811878 @default.
- W2072612850 cites W1977281954 @default.
- W2072612850 cites W1978060324 @default.
- W2072612850 cites W1979887297 @default.
- W2072612850 cites W1984761779 @default.
- W2072612850 cites W1985858988 @default.
- W2072612850 cites W1986214293 @default.
- W2072612850 cites W1987564805 @default.
- W2072612850 cites W1989072027 @default.
- W2072612850 cites W1990108688 @default.
- W2072612850 cites W1991210857 @default.
- W2072612850 cites W1993326230 @default.
- W2072612850 cites W1993546257 @default.
- W2072612850 cites W1999600810 @default.
- W2072612850 cites W2000313096 @default.
- W2072612850 cites W2002081448 @default.
- W2072612850 cites W2002304297 @default.
- W2072612850 cites W2002517161 @default.
- W2072612850 cites W2003122504 @default.
- W2072612850 cites W2004254503 @default.
- W2072612850 cites W2004781757 @default.
- W2072612850 cites W2005170146 @default.
- W2072612850 cites W2005556449 @default.
- W2072612850 cites W2009038500 @default.
- W2072612850 cites W2009482334 @default.
- W2072612850 cites W2013010261 @default.
- W2072612850 cites W2022322831 @default.
- W2072612850 cites W2022765714 @default.
- W2072612850 cites W2023933505 @default.
- W2072612850 cites W2024256121 @default.
- W2072612850 cites W2024523964 @default.
- W2072612850 cites W2025036947 @default.
- W2072612850 cites W2031630601 @default.
- W2072612850 cites W2031984782 @default.
- W2072612850 cites W2033715508 @default.
- W2072612850 cites W2034365190 @default.
- W2072612850 cites W2036811391 @default.
- W2072612850 cites W2039097438 @default.
- W2072612850 cites W2040393410 @default.
- W2072612850 cites W2050085273 @default.
- W2072612850 cites W2053449083 @default.
- W2072612850 cites W2055655700 @default.
- W2072612850 cites W2055722933 @default.
- W2072612850 cites W2057042537 @default.
- W2072612850 cites W2059927830 @default.
- W2072612850 cites W2060044923 @default.
- W2072612850 cites W2060110225 @default.
- W2072612850 cites W2063250637 @default.
- W2072612850 cites W2063729179 @default.
- W2072612850 cites W2064813013 @default.
- W2072612850 cites W2070657541 @default.
- W2072612850 cites W2074270121 @default.
- W2072612850 cites W2081030263 @default.
- W2072612850 cites W2085882810 @default.
- W2072612850 cites W2090742333 @default.
- W2072612850 cites W2091467458 @default.
- W2072612850 cites W2094434788 @default.
- W2072612850 cites W2102037532 @default.
- W2072612850 cites W2108713158 @default.
- W2072612850 cites W2110133792 @default.
- W2072612850 cites W2116628043 @default.
- W2072612850 cites W2118878458 @default.
- W2072612850 cites W2121621281 @default.
- W2072612850 cites W2122241249 @default.
- W2072612850 cites W2139713707 @default.
- W2072612850 cites W2140082856 @default.
- W2072612850 cites W2140379022 @default.
- W2072612850 cites W2149601493 @default.
- W2072612850 cites W2154023987 @default.
- W2072612850 cites W2155056678 @default.
- W2072612850 cites W2157215646 @default.
- W2072612850 cites W2159789252 @default.
- W2072612850 cites W2161144658 @default.
- W2072612850 cites W2161580101 @default.
- W2072612850 cites W2166227856 @default.
- W2072612850 cites W2169283286 @default.
- W2072612850 cites W2188775934 @default.
- W2072612850 cites W2220854812 @default.
- W2072612850 cites W2282219349 @default.
- W2072612850 cites W2313040660 @default.
- W2072612850 cites W2314253289 @default.