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• W2072616338 abstract "The fosmidomycin derivative FR900098 represents an inhibitor of the 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase with potent antimalarial activity. Prodrugs of FR900098 with increased activity after oral administration were obtained by chemical modification of the phosphonate moiety to yield phosphodiaryl esters. One diaryl ester prodrug demonstrated efficacy in mice infected with the rodent malaria parasite Plasmodium vinckei comparable to i.p. drug administration." @default.
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• W2072616338 date "2001-03-01" @default.
• W2072616338 modified "2023-09-27" @default.
• W2072616338 title "Diaryl ester prodrugs of fR900098 with improved in vivo antimalarial activity" @default.
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• W2072616338 doi "https://doi.org/10.1016/s0960-894x(01)00075-0" @default.
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