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- W2072631310 abstract "1 A series of studies has been conducted to investigate the disposition of nicardipine following oral and intravenous administration to human subjects. 2 Nicardipine is rapidly absorbed, rapidly and extensively metabolised and rapidly eliminated from plasma. 3 Nicardipine is subject to extensive pre-systemic elimination. This is partially saturable by increasing dose or duration of dosing. 4 Because of nicardipine's saturable pre-systemic elimination, steady-state plasma levels and bioavailability show a non-linear relationship with dose over the range 10 to 40 mg three times daily. 5 On repeated oral administration steady-state levels are apparently achieved within 3 days without subsequent change. This is consistent with the measured terminal elimination half-life of 11.8 h, and a demonstrated absence of effect on hepatic microsomal enzyme systems. 6 Consumption of food before nicardipine administration reduces its bioavailability. 7 Studies in the elderly have demonstrated that increased hypotensive effects with age cannot be attributed to pharmacokinetic changes. 8 Studies in renally impaired subjects have demonstrated that dosage at the lower end of the recommended range is appropriate." @default.
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- W2072631310 date "1986-12-01" @default.
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- W2072631310 title "A review of the human metabolism and pharmacokinetics of nicardipine hydrochloride" @default.
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- W2072631310 doi "https://doi.org/10.1111/j.1365-2125.1986.tb00322.x" @default.
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