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- W2072631690 abstract "can be cured, rather than in those patients with distressing symptoms that need to be palliated. But, perhaps things are changing. Bone metastasis has an incidence of around 100,000 new cases per year in the United States, and a frequent problem in patients with prostate, breast, and lung cancer. Bone metastasis can be associated with severe pain, debilitation, and a reduction in “quality-of-life” with severe socioeconomic impacts. The treatment from bone metastasis has ranged from nihilism through unwarranted optimism using treatments ranging from narcotics analgesia to aggressive cytotoxic chemotherapy, together with local and wide field irradiation techniques, and radiopharmaceuticals such as strontium-89. The basic tenets of palliation have not changed, however. Probably the most important tenet when treating in the palliative setting is to remove the distressing symptom as quickly, and effectively as possible. External beam radiotherapy has an established role in the palliation of bone metastases, with complete and partial response rates greater than 75%. An important question that has been debated has been the choice of dose fractionation and volume. The European and Canadian database have favored the use of single or few fractions to palliate symptoms related to bony metastases. While this on face value appears to be the probable effective way in keeping with the understanding principals associated with optimum palliation, we must remember that many of the evaluation techniques used did not rigorously evaluate patients following treatment, and we" @default.
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- W2072631690 title "Palliative irradiation for bone metastasis—a new paradigm" @default.
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- W2072631690 doi "https://doi.org/10.1016/0360-3016(94)90421-9" @default.
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