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- W2072667733 abstract "On the basis of calculated cumulative hazard rates for initial occurrence of adverse experiences of patients following treatment for rheumatoid arthritis and osteoarthritis, a simple function is evolved that fits such cumulative hazard rate data very well. From this simple function, we obtain the estimated hazard rate in terms of two physically meaningful parameters. These two parameters can be used to describe the rate of occurrence of adverse experiences, and to convey the concept of risk of adverse experience associated with duration of exposure to a drug. The parameters are ρ1, which represents the risk of adverse experience at baseline, and ρ2, which defines the rate of occurrence of adverse experience immediately following drug administration. A method of estimating ρ1 and ρ2 is the maximum likelihood approach." @default.
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- W2072667733 date "1991-01-01" @default.
- W2072667733 modified "2023-09-23" @default.
- W2072667733 title "Applying survival methodology to adverse experience occurrences in controlled clinical trials" @default.
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- W2072667733 doi "https://doi.org/10.1080/10543409108835005" @default.
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