Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072673226> ?p ?o ?g. }
- W2072673226 endingPage "972" @default.
- W2072673226 startingPage "967" @default.
- W2072673226 abstract "Losartan and antiplatelet agent ticlopidine can be prescribed concomitantly for prevention or therapy of cardiovascular diseases. Hence, the effects of ticlopidine on the pharmacokinetics of losartan and its active metabolite EXP-3174 were evaluated in rats.Ticlopidine (4 or 10 mg/kg po) was administered 30 min before administration of losartan (9 mg/kg po or 3 mg/kg iv). The activity of human CYP2C9 and 3A4 were measured using the CYP inhibition assay kit. The activity of P-gp was evaluated using rhodamine-123 retention assay in MCF-7/ADR cells.Ticlopidine (10 mg/kg) significantly increased the areas under the plasma concentration-time curves (AUCs) and peak plasma concentration (C(max)) of oral losartan (9 mg/kg), as well as the AUCs of the active metabolite EXP-3174. Ticlopidine (10 mg/kg) did not significantly change the pharmacokinetics of intravenous losartan (3 mg/kg). Ticlopidine inhibited CYP2C9 and 3A4 with IC₅₀ values of 26.0 and 32.3 μmol/L, respectively. The relative cellular uptake of rhodamine-123 was unchanged.The significant increase in the AUC of losartan (9 mg/kg) by ticlopidine (10 mg/kg) could be attributed to the inhibition of CYP2C9- and 3A4-mediated losartan metabolism in small intestine and/or in liver. The inhibition of P-gp in small intestine and reduction of renal elimination of losartan by ticlopidine are unlikely to be causal factors." @default.
- W2072673226 created "2016-06-24" @default.
- W2072673226 creator A5011692309 @default.
- W2072673226 creator A5014937732 @default.
- W2072673226 creator A5016792207 @default.
- W2072673226 date "2011-06-13" @default.
- W2072673226 modified "2023-10-11" @default.
- W2072673226 title "Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats" @default.
- W2072673226 cites W1493745198 @default.
- W2072673226 cites W1926446557 @default.
- W2072673226 cites W1967137561 @default.
- W2072673226 cites W1972212193 @default.
- W2072673226 cites W1976421128 @default.
- W2072673226 cites W2007788734 @default.
- W2072673226 cites W2009649574 @default.
- W2072673226 cites W2018753489 @default.
- W2072673226 cites W2018858039 @default.
- W2072673226 cites W2031658817 @default.
- W2072673226 cites W2048760599 @default.
- W2072673226 cites W2066806870 @default.
- W2072673226 cites W2082201249 @default.
- W2072673226 cites W2085676297 @default.
- W2072673226 cites W2097712021 @default.
- W2072673226 cites W2098074377 @default.
- W2072673226 cites W2118372925 @default.
- W2072673226 cites W2135998381 @default.
- W2072673226 cites W2265558272 @default.
- W2072673226 cites W2327232426 @default.
- W2072673226 cites W2334447534 @default.
- W2072673226 cites W2502670554 @default.
- W2072673226 cites W4249856491 @default.
- W2072673226 doi "https://doi.org/10.1038/aps.2011.32" @default.
- W2072673226 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4003123" @default.
- W2072673226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21666702" @default.
- W2072673226 hasPublicationYear "2011" @default.
- W2072673226 type Work @default.
- W2072673226 sameAs 2072673226 @default.
- W2072673226 citedByCount "17" @default.
- W2072673226 countsByYear W20726732262013 @default.
- W2072673226 countsByYear W20726732262014 @default.
- W2072673226 countsByYear W20726732262015 @default.
- W2072673226 countsByYear W20726732262016 @default.
- W2072673226 countsByYear W20726732262017 @default.
- W2072673226 countsByYear W20726732262018 @default.
- W2072673226 countsByYear W20726732262020 @default.
- W2072673226 countsByYear W20726732262021 @default.
- W2072673226 crossrefType "journal-article" @default.
- W2072673226 hasAuthorship W2072673226A5011692309 @default.
- W2072673226 hasAuthorship W2072673226A5014937732 @default.
- W2072673226 hasAuthorship W2072673226A5016792207 @default.
- W2072673226 hasBestOaLocation W20726732261 @default.
- W2072673226 hasConcept C112705442 @default.
- W2072673226 hasConcept C134018914 @default.
- W2072673226 hasConcept C149151106 @default.
- W2072673226 hasConcept C170493617 @default.
- W2072673226 hasConcept C185592680 @default.
- W2072673226 hasConcept C2777056448 @default.
- W2072673226 hasConcept C2777477808 @default.
- W2072673226 hasConcept C2777628954 @default.
- W2072673226 hasConcept C2777849778 @default.
- W2072673226 hasConcept C2778905298 @default.
- W2072673226 hasConcept C2780288358 @default.
- W2072673226 hasConcept C2908929049 @default.
- W2072673226 hasConcept C3946865 @default.
- W2072673226 hasConcept C526171541 @default.
- W2072673226 hasConcept C55493867 @default.
- W2072673226 hasConcept C62231903 @default.
- W2072673226 hasConcept C71924100 @default.
- W2072673226 hasConcept C98274493 @default.
- W2072673226 hasConceptScore W2072673226C112705442 @default.
- W2072673226 hasConceptScore W2072673226C134018914 @default.
- W2072673226 hasConceptScore W2072673226C149151106 @default.
- W2072673226 hasConceptScore W2072673226C170493617 @default.
- W2072673226 hasConceptScore W2072673226C185592680 @default.
- W2072673226 hasConceptScore W2072673226C2777056448 @default.
- W2072673226 hasConceptScore W2072673226C2777477808 @default.
- W2072673226 hasConceptScore W2072673226C2777628954 @default.
- W2072673226 hasConceptScore W2072673226C2777849778 @default.
- W2072673226 hasConceptScore W2072673226C2778905298 @default.
- W2072673226 hasConceptScore W2072673226C2780288358 @default.
- W2072673226 hasConceptScore W2072673226C2908929049 @default.
- W2072673226 hasConceptScore W2072673226C3946865 @default.
- W2072673226 hasConceptScore W2072673226C526171541 @default.
- W2072673226 hasConceptScore W2072673226C55493867 @default.
- W2072673226 hasConceptScore W2072673226C62231903 @default.
- W2072673226 hasConceptScore W2072673226C71924100 @default.
- W2072673226 hasConceptScore W2072673226C98274493 @default.
- W2072673226 hasIssue "7" @default.
- W2072673226 hasLocation W20726732261 @default.
- W2072673226 hasLocation W20726732262 @default.
- W2072673226 hasLocation W20726732263 @default.
- W2072673226 hasLocation W20726732264 @default.
- W2072673226 hasOpenAccess W2072673226 @default.
- W2072673226 hasPrimaryLocation W20726732261 @default.
- W2072673226 hasRelatedWork W1967453139 @default.
- W2072673226 hasRelatedWork W1998356222 @default.
- W2072673226 hasRelatedWork W2018753489 @default.
- W2072673226 hasRelatedWork W2030336508 @default.