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• W2072676793 abstract "This study examines the potential for a ventilatory drive, independent of mean Pco 2 , but depending instead on changes in Pco 2 that occur during the respiratory cycle. This responsiveness is referred to here as “dynamic ventilatory sensitivity.” The normal, spontaneous, respiratory oscillations in alveolar Pco 2 have been modified with inspiratory pulses approximating alveolar Pco 2 concentrations, both at sea level and at high altitude (5,000 m, 16,400 ft.). All tests were conducted with subjects exercising on a cycle ergometer at 60 W. The pulses last about half the inspiratory duration and are timed to arrive in the alveoli during early or late inspiration. Differences in ventilation, which then occur in the face of similar end-tidal Pco 2 values, are taken to result from dynamic ventilatory sensitivity. Highly significant ventilatory responses (early pulse response greater than late) occurred in hypoxia and normoxia at sea level and after more than 4 days at 5,000 m. The response at high altitude was eliminated by normalizing Po 2 and was reduced or eliminated with acetazolamide. No response was present soon after arrival (<4 days) at base camp, 5,000 m, on either of two high-altitude expeditions (BMEME, 1994, and Kanchenjunga, 1998). The largest responses at 5,000 m were obtained in subjects returning from very high altitude (7,100–8,848 m). The present study confirms and extends previous investigations that suggest that alveolar Pco 2 oscillations provide a feedback signal for respiratory control, independent of changes in mean Pco 2 , suggesting that natural Pco 2 oscillations drive breathing in exercise." @default.
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• W2072676793 date "2008-02-01" @default.
• W2072676793 modified "2023-10-15" @default.
• W2072676793 title "Alveolar P<scp>co</scp>₂ oscillations and ventilation at sea level and at high altitude" @default.
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• W2072676793 doi "https://doi.org/10.1152/japplphysiol.00166.2007" @default.
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