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• W2072684069 abstract "The CYP3A5 gene (CYP3A5) encodes the cytochrome P450 3A5, which catalyzes the 6beta-hydroxylation of testosterone. We explored association between the CYP3A5 A6986G polymorphism and a risk of prostate cancer in 260 prostate cancer patients, 199 BPH patients and 212 male controls. The CYP3A5 gene polymorphism did not influence significantly a risk of developing of prostate cancer in general. However, compared with males with the GG genotype, those with the AA genotype had a 0.23-fold decreased risk of developing low-grade prostate cancer (P=0.023), and a 0.31-fold decreased risk of developing localized (stages A-C) prostate cancer (P=0.044). The CYP3A5 A6986G polymorphism may be specifically associated with a decreased risk of low-grade or early stage prostate cancer." @default.
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• W2072684069 date "2005-07-01" @default.
• W2072684069 modified "2023-10-09" @default.
• W2072684069 title "CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population" @default.
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• W2072684069 doi "https://doi.org/10.1016/j.canlet.2005.03.009" @default.
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