Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072684552> ?p ?o ?g. }
- W2072684552 endingPage "667" @default.
- W2072684552 startingPage "667" @default.
- W2072684552 abstract "Identification of atrophy of the subgenual anterior cingulate cortex, in particular the subcallosal area, as an effective auxiliary means of diagnosis for major depressive disorder Akira Niida,1 Richi Niida,2 Hiroshi Matsuda,3 Takashi Inada,4 Makoto Motomura,5 Akihiko Uechi61Department of Radiology, Nanbu Hospital, Itoman City, Okinawa, 2Department of Psychiatry, Nanto Clinic, Urasoe City, Okinawa, 3Department of Nuclear Medicine, Saitama Medical University International Medical Center, Hidaka City, Saitama, 4Department of Psychiatry, Kai Clinic, Naha City, Okinawa, 5Department of Human Sciences, University of the Ryukyu, Nakagami County, Okinawa, 6Cognitive Neuroscience Research Project, Kansai Gaidai University, Hirakata City, Osaka, JapanBackground: Despite being a very common psychiatric disorder, physicians often have difficulty making a diagnosis of major depressive disorder (MDD) because, without established diagnostic criteria, they have to depend on interviews with patients and observation to assess psychiatric symptoms. However, previous researchers have reported that magnetic resonance imaging (MRI) scans identify morphological changes in the brains of patients with MDD, which inspired us to hypothesize that assessment of local changes in the brain using voxel-based morphometry would serve as an auxiliary diagnostic method for MDD. Therefore, we focused on the VSRAD® plus (voxel-based specific regional analysis system for Alzheimer’s disease), a diagnostic support system for use in early Alzheimer’s disease, which allowed us to identify regional atrophy in the brain easily based on images obtained from MRI scans.Methods: The subjects were 75 patients with MDD, 15 with bipolar disorder, and 30 healthy subjects, aged 54–82 years. First, 1.5 T MRI equipment was used to scan three-dimensional T1-weighted images for the individual subjects, and the imaged data were analyzed by VSRAD advance (voxel-based morphometric software developed for diagnosis of early Alzheimer’s disease). The efficacy of the equipment for diagnosis of MDD was evaluated based on the distribution of atrophy in the subgenual anterior cingulate cortex (sACC) on the z-score map obtained.Results: No significant difference in atrophy was noted between the left and right sACCs. The VSRAD advance used in the present study was more effective than the VSRAD plus for diagnosis of MDD, with a sensitivity of 90.7%, specificity of 86.7%, accuracy of 89.5%, a positive predictive value of 94.4%, and a negative predictive value of 78.8%. In particular, atrophy was observed in the subcallosal area of the sACC.Conclusion: The identification of atrophy in the sACC, in particular of the subcallosal area, with the use of updated voxel-based morphometric software proved to be effective as an auxiliary diagnostic method for MDD.Keywords: major depressive disorder, magnetic resonance imaging, subgenual anterior cingulate cortex, voxel-based morphometry, VSRAD" @default.
- W2072684552 created "2016-06-24" @default.
- W2072684552 creator A5017758018 @default.
- W2072684552 creator A5048278243 @default.
- W2072684552 creator A5049132072 @default.
- W2072684552 creator A5066539878 @default.
- W2072684552 creator A5080015573 @default.
- W2072684552 creator A5089702198 @default.
- W2072684552 date "2012-08-01" @default.
- W2072684552 modified "2023-10-16" @default.
- W2072684552 title "Identification of atrophy of the subgenual anterior cingulate cortex, in particular the subcallosal area, as an effective auxiliary means of diagnosis for major depressive disorder" @default.
- W2072684552 cites W1524661139 @default.
- W2072684552 cites W1582811168 @default.
- W2072684552 cites W1649142435 @default.
- W2072684552 cites W1970488531 @default.
- W2072684552 cites W1972717007 @default.
- W2072684552 cites W1974077854 @default.
- W2072684552 cites W1982100689 @default.
- W2072684552 cites W1989297136 @default.
- W2072684552 cites W1990168531 @default.
- W2072684552 cites W1992474739 @default.
- W2072684552 cites W1999475962 @default.
- W2072684552 cites W2023464568 @default.
- W2072684552 cites W2041583787 @default.
- W2072684552 cites W2044710410 @default.
- W2072684552 cites W2048738245 @default.
- W2072684552 cites W2053859325 @default.
- W2072684552 cites W2058608956 @default.
- W2072684552 cites W2059793861 @default.
- W2072684552 cites W2061099394 @default.
- W2072684552 cites W2075971518 @default.
- W2072684552 cites W2077280897 @default.
- W2072684552 cites W2098894213 @default.
- W2072684552 cites W2123986712 @default.
- W2072684552 cites W2125629287 @default.
- W2072684552 cites W2133382659 @default.
- W2072684552 cites W2133518193 @default.
- W2072684552 cites W2135947496 @default.
- W2072684552 cites W2155298532 @default.
- W2072684552 cites W2156743186 @default.
- W2072684552 cites W2160753858 @default.
- W2072684552 cites W2162196924 @default.
- W2072684552 doi "https://doi.org/10.2147/ijgm.s34093" @default.
- W2072684552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3422897" @default.
- W2072684552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22924012" @default.
- W2072684552 hasPublicationYear "2012" @default.
- W2072684552 type Work @default.
- W2072684552 sameAs 2072684552 @default.
- W2072684552 citedByCount "12" @default.
- W2072684552 countsByYear W20726845522013 @default.
- W2072684552 countsByYear W20726845522014 @default.
- W2072684552 countsByYear W20726845522015 @default.
- W2072684552 countsByYear W20726845522016 @default.
- W2072684552 countsByYear W20726845522018 @default.
- W2072684552 countsByYear W20726845522021 @default.
- W2072684552 countsByYear W20726845522022 @default.
- W2072684552 countsByYear W20726845522023 @default.
- W2072684552 crossrefType "journal-article" @default.
- W2072684552 hasAuthorship W2072684552A5017758018 @default.
- W2072684552 hasAuthorship W2072684552A5048278243 @default.
- W2072684552 hasAuthorship W2072684552A5049132072 @default.
- W2072684552 hasAuthorship W2072684552A5066539878 @default.
- W2072684552 hasAuthorship W2072684552A5080015573 @default.
- W2072684552 hasAuthorship W2072684552A5089702198 @default.
- W2072684552 hasBestOaLocation W20726845521 @default.
- W2072684552 hasConcept C118552586 @default.
- W2072684552 hasConcept C126838900 @default.
- W2072684552 hasConcept C142724271 @default.
- W2072684552 hasConcept C169900460 @default.
- W2072684552 hasConcept C2778402161 @default.
- W2072684552 hasConcept C2779134260 @default.
- W2072684552 hasConcept C2780051608 @default.
- W2072684552 hasConcept C2781172350 @default.
- W2072684552 hasConcept C54170458 @default.
- W2072684552 hasConcept C71924100 @default.
- W2072684552 hasConceptScore W2072684552C118552586 @default.
- W2072684552 hasConceptScore W2072684552C126838900 @default.
- W2072684552 hasConceptScore W2072684552C142724271 @default.
- W2072684552 hasConceptScore W2072684552C169900460 @default.
- W2072684552 hasConceptScore W2072684552C2778402161 @default.
- W2072684552 hasConceptScore W2072684552C2779134260 @default.
- W2072684552 hasConceptScore W2072684552C2780051608 @default.
- W2072684552 hasConceptScore W2072684552C2781172350 @default.
- W2072684552 hasConceptScore W2072684552C54170458 @default.
- W2072684552 hasConceptScore W2072684552C71924100 @default.
- W2072684552 hasLocation W20726845521 @default.
- W2072684552 hasLocation W20726845522 @default.
- W2072684552 hasLocation W20726845523 @default.
- W2072684552 hasLocation W20726845524 @default.
- W2072684552 hasOpenAccess W2072684552 @default.
- W2072684552 hasPrimaryLocation W20726845521 @default.
- W2072684552 hasRelatedWork W1832900872 @default.
- W2072684552 hasRelatedWork W1997194251 @default.
- W2072684552 hasRelatedWork W2075971518 @default.
- W2072684552 hasRelatedWork W2098128396 @default.
- W2072684552 hasRelatedWork W2150949665 @default.
- W2072684552 hasRelatedWork W2344520703 @default.
- W2072684552 hasRelatedWork W2897165279 @default.