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• W2072699609 abstract "Costs and benefits of the immune response have attracted considerable attention in the last years among evolutionary biologists. Given the cost of parasitism, natural selection should favor individuals with the most effective immune defenses. Nevertheless, there exists huge variation in the expression of immune effectors among individuals. To explain this apparent paradox, it has been suggested that an over-reactive immune system might be too costly, both in terms of metabolic resources and risks of immune-mediated diseases, setting a limit to the investment into immune defenses. Here, we argue that this view neglects one important aspect of the interaction: the role played by evolving pathogens. We suggest that taking into account the co-evolutionary interactions between the host immune system and the parasitic strategies to overcome the immune response might provide a better picture of the selective pressures that shape the evolution of immune functioning. Integrating parasitic strategies of host exploitation can also contribute to understand the seemingly contradictory results that infection can enhance, but also protect from, autoimmune diseases. In the last decades, the incidence of autoimmune disorders has dramatically increased in wealthy countries of the northern hemisphere with a concomitant decrease of most parasitic infections. Experimental work on model organisms has shown that this pattern may be due to the protective role of certain parasites (i.e., helminths) that rely on the immunosuppression of hosts for their persistence. Interestingly, although parasite-induced immunosuppression can protect against autoimmunity, it can obviously favor the spread of other infections. Therefore, we need to think about the evolution of the immune system using a multidimensional trade-off involving immunoprotection, immunopathology and the parasitic strategies to escape the immune response." @default.
• W2072699609 created "2016-06-24" @default.
• W2072699609 creator A5037349041 @default.
• W2072699609 creator A5067267094 @default.
• W2072699609 creator A5071959463 @default.
• W2072699609 date "2013-02-13" @default.
• W2072699609 modified "2023-10-16" @default.
• W2072699609 title "Immune Evasion, Immunopathology and the Regulation of the Immune System" @default.
• W2072699609 cites W1486722793 @default.
• W2072699609 cites W1521212256 @default.
• W2072699609 cites W1531483827 @default.
• W2072699609 cites W1546831560 @default.
• W2072699609 cites W1642011293 @default.
• W2072699609 cites W1663392211 @default.
• W2072699609 cites W1777264516 @default.
• W2072699609 cites W1965727970 @default.
• W2072699609 cites W1968568784 @default.
• W2072699609 cites W1968961392 @default.
• W2072699609 cites W1972859381 @default.
• W2072699609 cites W1973648078 @default.
• W2072699609 cites W1978883524 @default.
• W2072699609 cites W1979791693 @default.
• W2072699609 cites W1979866498 @default.
• W2072699609 cites W1980673401 @default.
• W2072699609 cites W1981826712 @default.
• W2072699609 cites W1982873334 @default.
• W2072699609 cites W1983345504 @default.
• W2072699609 cites W1984070341 @default.
• W2072699609 cites W1984643976 @default.
• W2072699609 cites W1986109976 @default.
• W2072699609 cites W1986411624 @default.
• W2072699609 cites W1991518398 @default.
• W2072699609 cites W1993371953 @default.
• W2072699609 cites W1993849783 @default.
• W2072699609 cites W1994094894 @default.
• W2072699609 cites W1994505708 @default.
• W2072699609 cites W1995837138 @default.
• W2072699609 cites W1998268789 @default.
• W2072699609 cites W2000587047 @default.
• W2072699609 cites W2003499486 @default.
• W2072699609 cites W2006075238 @default.
• W2072699609 cites W2008139833 @default.
• W2072699609 cites W2010092425 @default.
• W2072699609 cites W2011601656 @default.
• W2072699609 cites W2016333231 @default.
• W2072699609 cites W2017596644 @default.
• W2072699609 cites W2018173725 @default.
• W2072699609 cites W2018577070 @default.
• W2072699609 cites W2019858577 @default.
• W2072699609 cites W2020320159 @default.
• W2072699609 cites W2029327703 @default.
• W2072699609 cites W2030603947 @default.
• W2072699609 cites W2032089153 @default.
• W2072699609 cites W2032594763 @default.
• W2072699609 cites W2035831689 @default.
• W2072699609 cites W2036564469 @default.
• W2072699609 cites W2040607164 @default.
• W2072699609 cites W2041224982 @default.
• W2072699609 cites W2041352234 @default.
• W2072699609 cites W2042854425 @default.
• W2072699609 cites W2045006688 @default.
• W2072699609 cites W2046064200 @default.
• W2072699609 cites W2048417796 @default.
• W2072699609 cites W2050703672 @default.
• W2072699609 cites W2054371333 @default.
• W2072699609 cites W2055809644 @default.
• W2072699609 cites W2061751962 @default.
• W2072699609 cites W2062382041 @default.
• W2072699609 cites W2065488410 @default.
• W2072699609 cites W2065773719 @default.
• W2072699609 cites W2067648924 @default.
• W2072699609 cites W2068164177 @default.
• W2072699609 cites W2071502595 @default.
• W2072699609 cites W2073234751 @default.
• W2072699609 cites W2075528117 @default.
• W2072699609 cites W2076009897 @default.
• W2072699609 cites W2076360783 @default.
• W2072699609 cites W2076819781 @default.
• W2072699609 cites W2077262948 @default.
• W2072699609 cites W2077822706 @default.
• W2072699609 cites W2081926413 @default.
• W2072699609 cites W2085279345 @default.
• W2072699609 cites W2086440440 @default.
• W2072699609 cites W2086499125 @default.
• W2072699609 cites W2089479018 @default.
• W2072699609 cites W2091483766 @default.
• W2072699609 cites W2092094591 @default.
• W2072699609 cites W2093765191 @default.
• W2072699609 cites W2095040060 @default.
• W2072699609 cites W2097728608 @default.
• W2072699609 cites W2098251798 @default.
• W2072699609 cites W2102600079 @default.
• W2072699609 cites W2103913523 @default.
• W2072699609 cites W2104999336 @default.
• W2072699609 cites W2105654355 @default.
• W2072699609 cites W2105772739 @default.
• W2072699609 cites W2107728953 @default.
• W2072699609 cites W2108590205 @default.

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