FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072709258> ?p ?o ?g. }

• W2072709258 endingPage "2603" @default.
• W2072709258 startingPage "2592" @default.
• W2072709258 abstract "Cells can sense and respond to mechanical signals over relatively long distances across fibrous extracellular matrices. Recently proposed models suggest that long-range force transmission can be attributed to the nonlinear elasticity or fibrous nature of collagen matrices, yet the mechanism whereby fibers align remains unknown. Moreover, cell shape and anisotropy of cellular contraction are not considered in existing models, although recent experiments have shown that they play crucial roles. Here, we explore all of the key factors that influence long-range force transmission in cell-populated collagen matrices: alignment of collagen fibers, responses to applied force, strain stiffening properties of the aligned fibers, aspect ratios of the cells, and the polarization of cellular contraction. A constitutive law accounting for mechanically driven collagen fiber reorientation is proposed. We systematically investigate the range of collagen-fiber alignment using both finite-element simulations and analytical calculations. Our results show that tension-driven collagen-fiber alignment plays a crucial role in force transmission. Small critical stretch for fiber alignment, large fiber stiffness and fiber strain-hardening behavior enable long-range interaction. Furthermore, the range of collagen-fiber alignment for elliptical cells with polarized contraction is much larger than that for spherical cells with diagonal contraction. A phase diagram showing the range of force transmission as a function of cell shape and polarization and matrix properties is presented. Our results are in good agreement with recent experiments, and highlight the factors that influence long-range force transmission, in particular tension-driven alignment of fibers. Our work has important relevance to biological processes including development, cancer metastasis, and wound healing, suggesting conditions whereby cells communicate over long distances." @default.
• W2072709258 created "2016-06-24" @default.
• W2072709258 creator A5004976391 @default.
• W2072709258 creator A5011906405 @default.
• W2072709258 creator A5031069096 @default.
• W2072709258 creator A5043340501 @default.
• W2072709258 creator A5045288947 @default.
• W2072709258 date "2014-12-01" @default.
• W2072709258 modified "2023-10-03" @default.
• W2072709258 title "Long-Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers" @default.
• W2072709258 cites W1500831274 @default.
• W2072709258 cites W1588127651 @default.
• W2072709258 cites W1966871331 @default.
• W2072709258 cites W1967894955 @default.
• W2072709258 cites W1991248456 @default.
• W2072709258 cites W1993488903 @default.
• W2072709258 cites W2004751440 @default.
• W2072709258 cites W2005568183 @default.
• W2072709258 cites W2007485712 @default.
• W2072709258 cites W2008652184 @default.
• W2072709258 cites W2011983343 @default.
• W2072709258 cites W2023683612 @default.
• W2072709258 cites W2025003977 @default.
• W2072709258 cites W2030019694 @default.
• W2072709258 cites W2030541652 @default.
• W2072709258 cites W2036690926 @default.
• W2072709258 cites W2041678725 @default.
• W2072709258 cites W2041779667 @default.
• W2072709258 cites W2063167928 @default.
• W2072709258 cites W2067011858 @default.
• W2072709258 cites W2074462333 @default.
• W2072709258 cites W2081671199 @default.
• W2072709258 cites W2081720885 @default.
• W2072709258 cites W2098291603 @default.
• W2072709258 cites W2100303404 @default.
• W2072709258 cites W2101728107 @default.
• W2072709258 cites W2102079607 @default.
• W2072709258 cites W2103220507 @default.
• W2072709258 cites W2113138993 @default.
• W2072709258 cites W2115205179 @default.
• W2072709258 cites W2127108170 @default.
• W2072709258 cites W2133809313 @default.
• W2072709258 cites W2144066197 @default.
• W2072709258 cites W2144112984 @default.
• W2072709258 cites W2154577866 @default.
• W2072709258 cites W2154851379 @default.
• W2072709258 cites W2162655381 @default.
• W2072709258 cites W2170320977 @default.
• W2072709258 cites W2476542314 @default.
• W2072709258 doi "https://doi.org/10.1016/j.bpj.2014.09.044" @default.
• W2072709258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4255175" @default.
• W2072709258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25468338" @default.
• W2072709258 hasPublicationYear "2014" @default.
• W2072709258 type Work @default.
• W2072709258 sameAs 2072709258 @default.
• W2072709258 citedByCount "246" @default.
• W2072709258 countsByYear W20727092582015 @default.
• W2072709258 countsByYear W20727092582016 @default.
• W2072709258 countsByYear W20727092582017 @default.
• W2072709258 countsByYear W20727092582018 @default.
• W2072709258 countsByYear W20727092582019 @default.
• W2072709258 countsByYear W20727092582020 @default.
• W2072709258 countsByYear W20727092582021 @default.
• W2072709258 countsByYear W20727092582022 @default.
• W2072709258 countsByYear W20727092582023 @default.
• W2072709258 crossrefType "journal-article" @default.
• W2072709258 hasAuthorship W2072709258A5004976391 @default.
• W2072709258 hasAuthorship W2072709258A5011906405 @default.
• W2072709258 hasAuthorship W2072709258A5031069096 @default.
• W2072709258 hasAuthorship W2072709258A5043340501 @default.
• W2072709258 hasAuthorship W2072709258A5045288947 @default.
• W2072709258 hasBestOaLocation W20727092581 @default.
• W2072709258 hasConcept C120665830 @default.
• W2072709258 hasConcept C121332964 @default.
• W2072709258 hasConcept C121854251 @default.
• W2072709258 hasConcept C12554922 @default.
• W2072709258 hasConcept C159985019 @default.
• W2072709258 hasConcept C185592680 @default.
• W2072709258 hasConcept C189165786 @default.
• W2072709258 hasConcept C192562407 @default.
• W2072709258 hasConcept C2779372316 @default.
• W2072709258 hasConcept C519885992 @default.
• W2072709258 hasConcept C55493867 @default.
• W2072709258 hasConcept C57879066 @default.
• W2072709258 hasConcept C85725439 @default.
• W2072709258 hasConcept C86803240 @default.
• W2072709258 hasConceptScore W2072709258C120665830 @default.
• W2072709258 hasConceptScore W2072709258C121332964 @default.
• W2072709258 hasConceptScore W2072709258C121854251 @default.
• W2072709258 hasConceptScore W2072709258C12554922 @default.
• W2072709258 hasConceptScore W2072709258C159985019 @default.
• W2072709258 hasConceptScore W2072709258C185592680 @default.
• W2072709258 hasConceptScore W2072709258C189165786 @default.
• W2072709258 hasConceptScore W2072709258C192562407 @default.
• W2072709258 hasConceptScore W2072709258C2779372316 @default.
• W2072709258 hasConceptScore W2072709258C519885992 @default.
• W2072709258 hasConceptScore W2072709258C55493867 @default.
• W2072709258 hasConceptScore W2072709258C57879066 @default.

• next