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• W2072710121 endingPage "F939" @default.
• W2072710121 startingPage "F932" @default.
• W2072710121 abstract "Hypotonicity stimulates transepithelial Na + reabsorption in renal A6 cells, but the mechanism for this stimulation is not fully understood. In the present study, we found that hypotonicity stimulated Na + reabsorption through increases in mRNA expression of the α-subunit of the epithelial Na + channel (α-ENaC). Hypotonicity decreases cytosolic Cl − concentration; therefore, we hypothesized that hypotonicity-induced decreases in cytosolic Cl − concentration could act as a signal to regulate Na + reabsorption through changes in α-ENaC mRNA expression. Treatment with the flavone apigenin, which activates the Na + -K + -2Cl − cotransporter and increases cytosolic Cl − concentration, markedly suppressed the hypotonicity-induced increase in α-ENaC mRNA expression. On the other hand, blockade of the Na + -K + -2Cl − cotransporter decreases cytosolic Cl − concentration and increased α-ENaC mRNA expression and Na + reabsorption. Blocking Cl − channels with 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) inhibited the hypotonicity-induced decrease in cytosolic Cl − concentration and suppressed the hypotonicity-induced increase in α-ENaC mRNA expression. Coapplication of NPPB and apigenin synergistically suppressed α-ENaC mRNA expression. Thus, in every case, changes in cytosolic Cl − concentration were associated with changes in α-ENaC mRNA expression and changes in Na + reabsorption: decreases in cytosolic Cl − concentration increased α-ENaC mRNA and increased Na + reabsorption, whereas increases in cytosolic Cl − concentration decreased α-ENaC mRNA and decreased Na + reabsorption. These findings support the hypothesis that changes in cytosolic Cl − concentration are an important and novel signal in hypotonicity-induced regulation of α-ENaC expression and Na + reabsorption." @default.
• W2072710121 created "2016-06-24" @default.
• W2072710121 creator A5028548827 @default.
• W2072710121 creator A5056790528 @default.
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• W2072710121 date "2004-11-01" @default.
• W2072710121 modified "2023-10-16" @default.
• W2072710121 title "Involvement of cytosolic Cl⁻ in osmoregulation of α-ENaC gene expression" @default.
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• W2072710121 doi "https://doi.org/10.1152/ajprenal.00131.2004" @default.
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