FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072715844> ?p ?o ?g. }

• W2072715844 endingPage "e158" @default.
• W2072715844 startingPage "e158" @default.
• W2072715844 abstract "The alpha-thalassaemias are the commonest genetic disorders of humans. It is generally believed that this high frequency reflects selection through a survival advantage against death from malaria; nevertheless, the epidemiological description of the relationships between alpha-thalassaemia, malaria, and other common causes of child mortality remains incomplete.We studied the alpha+-thalassaemia-specific incidence of malaria and other common childhood diseases in two cohorts of children living on the coast of Kenya. We found no associations between alpha+-thalassaemia and the prevalence of symptomless Plasmodium falciparum parasitaemia, the incidence of uncomplicated P. falciparum disease, or parasite densities during mild or severe malaria episodes. However, we found significant negative associations between alpha+-thalassaemia and the incidence rates of severe malaria and severe anaemia (haemoglobin concentration < 50 g/l). The strongest associations were for severe malaria anaemia (> 10,000 P. falciparum parasites/mul) and severe nonmalaria anaemia; the incidence rate ratios and 95% confidence intervals (CIs) for alpha+-thalassaemia heterozygotes and homozygotes combined compared to normal children were, for severe malaria anaemia, 0.33 (95% CI, 0.15,0.73; p = 0.006), and for severe nonmalaria anaemia, 0.26 (95% CI, 0.09,0.77; p = 0.015).Our observations suggest, first that selection for alpha+-thalassaemia might be mediated by a specific effect against severe anaemia, an observation that may lead to fresh insights into the aetiology of this important condition. Second, although alpha+-thalassaemia is strongly protective against severe and fatal malaria, its effects are not detectable at the level of any other malaria outcome; this result provides a cautionary example for studies aimed at testing malaria interventions or identifying new malaria-protective genes." @default.
• W2072715844 created "2016-06-24" @default.
• W2072715844 creator A5006426246 @default.
• W2072715844 creator A5014066641 @default.
• W2072715844 creator A5028638805 @default.
• W2072715844 creator A5029161007 @default.
• W2072715844 creator A5044294572 @default.
• W2072715844 creator A5045503264 @default.
• W2072715844 creator A5055457328 @default.
• W2072715844 creator A5072332085 @default.
• W2072715844 creator A5075569206 @default.
• W2072715844 creator A5086801648 @default.
• W2072715844 date "2006-04-18" @default.
• W2072715844 modified "2023-10-17" @default.
• W2072715844 title "The Effect of α +-Thalassaemia on the Incidence of Malaria and Other Diseases in Children Living on the Coast of Kenya" @default.
• W2072715844 cites W1585156201 @default.
• W2072715844 cites W1893514523 @default.
• W2072715844 cites W1964733260 @default.
• W2072715844 cites W1969180772 @default.
• W2072715844 cites W1977303075 @default.
• W2072715844 cites W1990356699 @default.
• W2072715844 cites W1992476588 @default.
• W2072715844 cites W1993646556 @default.
• W2072715844 cites W1996218267 @default.
• W2072715844 cites W1998684905 @default.
• W2072715844 cites W2001296099 @default.
• W2072715844 cites W2003472864 @default.
• W2072715844 cites W2011186101 @default.
• W2072715844 cites W2018469646 @default.
• W2072715844 cites W2018871060 @default.
• W2072715844 cites W2019823288 @default.
• W2072715844 cites W2032181997 @default.
• W2072715844 cites W2034645256 @default.
• W2072715844 cites W2045431209 @default.
• W2072715844 cites W2053400987 @default.
• W2072715844 cites W2060637195 @default.
• W2072715844 cites W2061358207 @default.
• W2072715844 cites W2066301396 @default.
• W2072715844 cites W2070005745 @default.
• W2072715844 cites W2082103274 @default.
• W2072715844 cites W2085588203 @default.
• W2072715844 cites W2093866426 @default.
• W2072715844 cites W2097177690 @default.
• W2072715844 cites W2104697202 @default.
• W2072715844 cites W2107934195 @default.
• W2072715844 cites W2112215430 @default.
• W2072715844 cites W2114221564 @default.
• W2072715844 cites W2114272562 @default.
• W2072715844 cites W2134135408 @default.
• W2072715844 cites W2137225401 @default.
• W2072715844 cites W2139032091 @default.
• W2072715844 cites W2148039399 @default.
• W2072715844 cites W2160888487 @default.
• W2072715844 cites W2258193300 @default.
• W2072715844 cites W2322213143 @default.
• W2072715844 cites W2403302911 @default.
• W2072715844 cites W2410245245 @default.
• W2072715844 cites W2461687932 @default.
• W2072715844 cites W4210967418 @default.
• W2072715844 cites W4253453896 @default.
• W2072715844 doi "https://doi.org/10.1371/journal.pmed.0030158" @default.
• W2072715844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1435778" @default.
• W2072715844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16605300" @default.
• W2072715844 hasPublicationYear "2006" @default.
• W2072715844 type Work @default.
• W2072715844 sameAs 2072715844 @default.
• W2072715844 citedByCount "147" @default.
• W2072715844 countsByYear W20727158442012 @default.
• W2072715844 countsByYear W20727158442013 @default.
• W2072715844 countsByYear W20727158442014 @default.
• W2072715844 countsByYear W20727158442015 @default.
• W2072715844 countsByYear W20727158442016 @default.
• W2072715844 countsByYear W20727158442017 @default.
• W2072715844 countsByYear W20727158442018 @default.
• W2072715844 countsByYear W20727158442019 @default.
• W2072715844 countsByYear W20727158442020 @default.
• W2072715844 countsByYear W20727158442021 @default.
• W2072715844 countsByYear W20727158442022 @default.
• W2072715844 countsByYear W20727158442023 @default.
• W2072715844 crossrefType "journal-article" @default.
• W2072715844 hasAuthorship W2072715844A5006426246 @default.
• W2072715844 hasAuthorship W2072715844A5014066641 @default.
• W2072715844 hasAuthorship W2072715844A5028638805 @default.
• W2072715844 hasAuthorship W2072715844A5029161007 @default.
• W2072715844 hasAuthorship W2072715844A5044294572 @default.
• W2072715844 hasAuthorship W2072715844A5045503264 @default.
• W2072715844 hasAuthorship W2072715844A5055457328 @default.
• W2072715844 hasAuthorship W2072715844A5072332085 @default.
• W2072715844 hasAuthorship W2072715844A5075569206 @default.
• W2072715844 hasAuthorship W2072715844A5086801648 @default.
• W2072715844 hasBestOaLocation W20727158441 @default.
• W2072715844 hasConcept C104317684 @default.
• W2072715844 hasConcept C107130276 @default.
• W2072715844 hasConcept C120665830 @default.
• W2072715844 hasConcept C121332964 @default.
• W2072715844 hasConcept C126322002 @default.
• W2072715844 hasConcept C135763542 @default.
• W2072715844 hasConcept C179755657 @default.

• next