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• W2072735811 abstract "A substitution mutation has been introduced into the c-abl locus of murine embryonic stem cells by homologous recombination between exogenously added DNA and the endogenous gene, and these cells have been used to generate chimeric mice. It is shown that the c-abl mutation was transmitted to progeny by several male chimeras. This work demonstrates the feasibility of germ-line transmission of a mutation introduced into a nonselectable autosomal gene by homologous recombination." @default.
• W2072735811 created "2016-06-24" @default.
• W2072735811 creator A5031225867 @default.
• W2072735811 creator A5071836467 @default.
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• W2072735811 date "1989-11-10" @default.
• W2072735811 modified "2023-10-13" @default.
• W2072735811 title "Germ-Line Transmission of a c- <i>abl</i> Mutation Produced by Targeted Gene Disruption in ES Cells" @default.
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• W2072735811 doi "https://doi.org/10.1126/science.2554496" @default.
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