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- W2072738169 abstract "The reaction of diazotized 2-amino-p-benzenedisulphonic acid with the nucleotides was investigated at several pH values. At pH 9 guanylic aicds react 60 times faster than any of the other common nucleotides. The reaction leads to an addition product which contains the phosphorus and the base of the nucleotides and the sulphur of the diazonium salt. At pH 2 and 22° the product decomposes over 10 h; at pH 9 it is stable for several days. The diazonium salt reacts with ribose, deoxyribose and ribose 5'-phosphate at rates comparable to that of the nucleotides other than guanylic acid, suggesting the sugar as the site of the slow reactions. These results suggest that the guanine residues of the nucleic acid molecules could selectively be labelled over the other." @default.
- W2072738169 created "2016-06-24" @default.
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- W2072738169 date "1965-01-01" @default.
- W2072738169 modified "2023-10-17" @default.
- W2072738169 title "Determination of base sequence in nucleic acids with the electron microscope II. The reaction of a guanine-selective marker with the mononucleotides" @default.
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- W2072738169 doi "https://doi.org/10.1016/0005-2787(65)90207-8" @default.
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