FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072740129> ?p ?o ?g. }

• W2072740129 endingPage "3639" @default.
• W2072740129 startingPage "3639" @default.
• W2072740129 abstract "PURPOSE. The pathogenesis of retinal ischemia results from a series of events involving changes in gene expression and inflammatory cytokines. Protein acetylation is an essential mechanism in regulating transcriptional and inflammatory events. The purpose of this study was to investigate the neuroprotective action of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) in a retinal ischemic model. METHODS. To investigate whether HDAC inhibition can reduce ischemic injury, rats were treated with TSA (2.5 mg/kg intraperitoneally) twice daily on days 0, 1, 2, and 3. Seven days after ischemic injury, morphometric and electroretinographic (ERG) analyses were used to assess retinal structure and function. Western blot and immunohistochemical analyses were used to evaluate TSA-induced changes in histone-H3 acetylation and MMP secretion. RESULTS. In vehicle-treated animals, ERG a- and b-waves from ischemic eyes were significantly reduced compared with contralateral responses. In addition, histologic examination of these eyes revealed significant degeneration of inner retinal layers. In rats treated with TSA, amplitudes of ERG a- and b-waves from ischemic eyes were significantly increased, and normal inner retina morphology was preserved. Ischemia also increased the levels of retinal TNF-alpha, which was blocked by TSA treatment. In astrocyte cultures, the addition of TNF-alpha (10 ng/mL) stimulated the secretion of MMP-1 and MMP-3, which were blocked by TSA (100 nM). CONCLUSIONS. These studies provide the first evidence that suppressing HDAC activity can protect the retina from ischemic injury. This neuroprotective response is associated with the suppression of retinal TNF-alpha expression and signaling. The use of HDAC inhibitors may provide a novel treatment for ischemic retinal injury." @default.
• W2072740129 created "2016-06-24" @default.
• W2072740129 creator A5003237382 @default.
• W2072740129 creator A5003376409 @default.
• W2072740129 creator A5009530332 @default.
• W2072740129 creator A5019901150 @default.
• W2072740129 creator A5061323145 @default.
• W2072740129 date "2010-07-01" @default.
• W2072740129 modified "2023-10-11" @default.
• W2072740129 title "Inhibition of Histone Deacetylase Protects the Retina from Ischemic Injury" @default.
• W2072740129 cites W143574421 @default.
• W2072740129 cites W1493846190 @default.
• W2072740129 cites W1605691389 @default.
• W2072740129 cites W1687504009 @default.
• W2072740129 cites W1968144200 @default.
• W2072740129 cites W1980870391 @default.
• W2072740129 cites W1982117704 @default.
• W2072740129 cites W1982422365 @default.
• W2072740129 cites W1985187876 @default.
• W2072740129 cites W1985991456 @default.
• W2072740129 cites W1986827231 @default.
• W2072740129 cites W1988372844 @default.
• W2072740129 cites W1993175393 @default.
• W2072740129 cites W2000235997 @default.
• W2072740129 cites W2005471059 @default.
• W2072740129 cites W2009811989 @default.
• W2072740129 cites W2010231609 @default.
• W2072740129 cites W2028138696 @default.
• W2072740129 cites W2035494593 @default.
• W2072740129 cites W2039577300 @default.
• W2072740129 cites W2040222339 @default.
• W2072740129 cites W2043097986 @default.
• W2072740129 cites W2043712123 @default.
• W2072740129 cites W2045659872 @default.
• W2072740129 cites W2052878943 @default.
• W2072740129 cites W2055335620 @default.
• W2072740129 cites W2057924308 @default.
• W2072740129 cites W2069727882 @default.
• W2072740129 cites W2072669480 @default.
• W2072740129 cites W2074427701 @default.
• W2072740129 cites W2081600388 @default.
• W2072740129 cites W2091387807 @default.
• W2072740129 cites W2091554988 @default.
• W2072740129 cites W2099803844 @default.
• W2072740129 cites W2101481997 @default.
• W2072740129 cites W2105180380 @default.
• W2072740129 cites W2120560949 @default.
• W2072740129 cites W2121264285 @default.
• W2072740129 cites W2132109173 @default.
• W2072740129 cites W2153353568 @default.
• W2072740129 cites W2161763646 @default.
• W2072740129 cites W2167141364 @default.
• W2072740129 cites W2168448928 @default.
• W2072740129 cites W2418499051 @default.
• W2072740129 cites W60487933 @default.
• W2072740129 doi "https://doi.org/10.1167/iovs.09-4538" @default.
• W2072740129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2904015" @default.
• W2072740129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20164449" @default.
• W2072740129 hasPublicationYear "2010" @default.
• W2072740129 type Work @default.
• W2072740129 sameAs 2072740129 @default.
• W2072740129 citedByCount "89" @default.
• W2072740129 countsByYear W20727401292012 @default.
• W2072740129 countsByYear W20727401292013 @default.
• W2072740129 countsByYear W20727401292014 @default.
• W2072740129 countsByYear W20727401292015 @default.
• W2072740129 countsByYear W20727401292016 @default.
• W2072740129 countsByYear W20727401292017 @default.
• W2072740129 countsByYear W20727401292018 @default.
• W2072740129 countsByYear W20727401292019 @default.
• W2072740129 countsByYear W20727401292020 @default.
• W2072740129 countsByYear W20727401292021 @default.
• W2072740129 countsByYear W20727401292022 @default.
• W2072740129 countsByYear W20727401292023 @default.
• W2072740129 crossrefType "journal-article" @default.
• W2072740129 hasAuthorship W2072740129A5003237382 @default.
• W2072740129 hasAuthorship W2072740129A5003376409 @default.
• W2072740129 hasAuthorship W2072740129A5009530332 @default.
• W2072740129 hasAuthorship W2072740129A5019901150 @default.
• W2072740129 hasAuthorship W2072740129A5061323145 @default.
• W2072740129 hasBestOaLocation W20727401292 @default.
• W2072740129 hasConcept C103796816 @default.
• W2072740129 hasConcept C104317684 @default.
• W2072740129 hasConcept C118487528 @default.
• W2072740129 hasConcept C126322002 @default.
• W2072740129 hasConcept C134018914 @default.
• W2072740129 hasConcept C169760540 @default.
• W2072740129 hasConcept C185592680 @default.
• W2072740129 hasConcept C25498285 @default.
• W2072740129 hasConcept C2776202225 @default.
• W2072740129 hasConcept C2776415932 @default.
• W2072740129 hasConcept C2777093970 @default.
• W2072740129 hasConcept C2777865847 @default.
• W2072740129 hasConcept C2778305200 @default.
• W2072740129 hasConcept C2779113765 @default.
• W2072740129 hasConcept C2780827179 @default.
• W2072740129 hasConcept C541997718 @default.
• W2072740129 hasConcept C55493867 @default.

• next