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- W2072742423 abstract "Airways responsiveness to a bronchodilator is frequently measured to assist in determining the cause of respiratory symptoms. Clinically, a greater than 15% improvement in the FEV1 is often used to define the increased response indicative of asthma. However, unlike other tests of lung function, reference standards derived from healthy members of a general population sample have never been reported. As part of a health survey carried out in Alberta, Canada, 2,609 subjects completed a standardized respiratory symptom questionnaire and had FEV1 measured before and 20 min after inhaling terbutaline sulfate via a 750-ml spacer device. Among asymptomatic never-smoking subjects with a FEV1 greater than 80% of predicted, the upper 95th percentile of bronchodilator response (BDR), when expressed as 100 x (FEV1 postBDR - FEV1 preBDR)/predicted baseline FEV1 averaged 9%. This value remained remarkably stable across gender, age (7 to 75 yr), and height groups, and deviated to 6% only when baseline FEV1 was greater than 120% of predicted. Consistent with other respiratory function variables, in which the upper limit of normal is often defined as the upper 95th percentile, our population-derived reference values provide a conceptual definition of BDR that can easily be applied to define increased response in the clinical setting." @default.
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- W2072742423 date "1988-08-01" @default.
- W2072742423 modified "2023-10-17" @default.
- W2072742423 title "Clinical Interpretation of Airway Response to a Bronchodilator: Epidemiologic Considerations" @default.
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- W2072742423 doi "https://doi.org/10.1164/ajrccm/138.2.317" @default.
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