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- W2072765495 abstract "Dollo's law, the concept that evolution is not substantively reversible, implies that the degradation of genetic information is sufficiently fast that genes or developmental pathways released from selective pressure will rapidly become nonfunctional. Using empirical data to assess the rate of loss of coding information in genes for proteins with varying degrees of tolerance to mutational change, we show that, in fact, there is a significant probability over evolutionary time scales of 0.5-6 million years for successful reactivation of silenced genes or lost developmental programs. Conversely, the reactivation of long (> 10 million years)-unexpressed genes and dormant developmental pathways is not possible unless function is maintained by other selective constraints; the classic example of the resurrection of hen's teeth is most likely an experimental artifact, and the experimental reactivation of the Archaeopteryx limb developmental program has been shown to be a misinterpretation. For groups undergoing adaptive radiations, lost features may flicker on and off, resulting in a distribution of character states that does not reflect the phylogeny of the group." @default.
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- W2072765495 date "1994-12-06" @default.
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- W2072765495 title "Dollo's law and the death and resurrection of genes." @default.
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- W2072765495 doi "https://doi.org/10.1073/pnas.91.25.12283" @default.
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