Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072771433> ?p ?o ?g. }
- W2072771433 endingPage "176" @default.
- W2072771433 startingPage "171" @default.
- W2072771433 abstract "Nicotinic acid has been used clinically for decades to control serum lipoproteins. Nicotinic acid lowers very low-density lipoprotein (VLDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and lipoprotein-a (LPa), and it is also effective in raising high-density lipoprotein (HDL)-cholesterol. However, nicotinic acid has several side effects in clinical use. The most notable is intense cutaneous vasodilation flushing on the upper body and face. We discovered a pyranopyrimidinedione series to be nicotinic acid receptor agonists. A potent nicotinic acid receptor agonist from this series {5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione}with reduced flushing side effect in dogs was identified." @default.
- W2072771433 created "2016-06-24" @default.
- W2072771433 creator A5002118005 @default.
- W2072771433 creator A5008164465 @default.
- W2072771433 creator A5018576405 @default.
- W2072771433 creator A5023174058 @default.
- W2072771433 creator A5032558963 @default.
- W2072771433 creator A5038794343 @default.
- W2072771433 creator A5038854125 @default.
- W2072771433 creator A5042502468 @default.
- W2072771433 creator A5042531611 @default.
- W2072771433 creator A5043671209 @default.
- W2072771433 creator A5045870442 @default.
- W2072771433 creator A5046742103 @default.
- W2072771433 creator A5047711440 @default.
- W2072771433 creator A5047765041 @default.
- W2072771433 creator A5051119122 @default.
- W2072771433 creator A5051624923 @default.
- W2072771433 creator A5059272199 @default.
- W2072771433 creator A5060068655 @default.
- W2072771433 creator A5072485296 @default.
- W2072771433 creator A5073299652 @default.
- W2072771433 creator A5076828679 @default.
- W2072771433 creator A5077210145 @default.
- W2072771433 creator A5091491172 @default.
- W2072771433 date "2010-12-08" @default.
- W2072771433 modified "2023-09-27" @default.
- W2072771433 title "Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia" @default.
- W2072771433 cites W1481564277 @default.
- W2072771433 cites W1483105549 @default.
- W2072771433 cites W1982134384 @default.
- W2072771433 cites W1982384322 @default.
- W2072771433 cites W1992812460 @default.
- W2072771433 cites W1996819821 @default.
- W2072771433 cites W2011051352 @default.
- W2072771433 cites W2017663351 @default.
- W2072771433 cites W2024900891 @default.
- W2072771433 cites W2026367340 @default.
- W2072771433 cites W2036484428 @default.
- W2072771433 cites W2040822208 @default.
- W2072771433 cites W2046991199 @default.
- W2072771433 cites W2048148906 @default.
- W2072771433 cites W2070855777 @default.
- W2072771433 cites W2076090516 @default.
- W2072771433 cites W2077954054 @default.
- W2072771433 cites W2078578691 @default.
- W2072771433 cites W2079795589 @default.
- W2072771433 cites W2090600090 @default.
- W2072771433 cites W2091229442 @default.
- W2072771433 cites W2092903282 @default.
- W2072771433 cites W2093232733 @default.
- W2072771433 cites W2098346876 @default.
- W2072771433 cites W2115572248 @default.
- W2072771433 cites W2130877850 @default.
- W2072771433 cites W2161396059 @default.
- W2072771433 cites W2168443670 @default.
- W2072771433 cites W2169033201 @default.
- W2072771433 cites W4233804225 @default.
- W2072771433 doi "https://doi.org/10.1021/ml100251u" @default.
- W2072771433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4017979" @default.
- W2072771433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24900295" @default.
- W2072771433 hasPublicationYear "2010" @default.
- W2072771433 type Work @default.
- W2072771433 sameAs 2072771433 @default.
- W2072771433 citedByCount "22" @default.
- W2072771433 countsByYear W20727714332012 @default.
- W2072771433 countsByYear W20727714332013 @default.
- W2072771433 countsByYear W20727714332014 @default.
- W2072771433 countsByYear W20727714332016 @default.
- W2072771433 countsByYear W20727714332017 @default.
- W2072771433 countsByYear W20727714332018 @default.
- W2072771433 countsByYear W20727714332019 @default.
- W2072771433 countsByYear W20727714332020 @default.
- W2072771433 countsByYear W20727714332021 @default.
- W2072771433 countsByYear W20727714332022 @default.
- W2072771433 crossrefType "journal-article" @default.
- W2072771433 hasAuthorship W2072771433A5002118005 @default.
- W2072771433 hasAuthorship W2072771433A5008164465 @default.
- W2072771433 hasAuthorship W2072771433A5018576405 @default.
- W2072771433 hasAuthorship W2072771433A5023174058 @default.
- W2072771433 hasAuthorship W2072771433A5032558963 @default.
- W2072771433 hasAuthorship W2072771433A5038794343 @default.
- W2072771433 hasAuthorship W2072771433A5038854125 @default.
- W2072771433 hasAuthorship W2072771433A5042502468 @default.
- W2072771433 hasAuthorship W2072771433A5042531611 @default.
- W2072771433 hasAuthorship W2072771433A5043671209 @default.
- W2072771433 hasAuthorship W2072771433A5045870442 @default.
- W2072771433 hasAuthorship W2072771433A5046742103 @default.
- W2072771433 hasAuthorship W2072771433A5047711440 @default.
- W2072771433 hasAuthorship W2072771433A5047765041 @default.
- W2072771433 hasAuthorship W2072771433A5051119122 @default.
- W2072771433 hasAuthorship W2072771433A5051624923 @default.
- W2072771433 hasAuthorship W2072771433A5059272199 @default.
- W2072771433 hasAuthorship W2072771433A5060068655 @default.
- W2072771433 hasAuthorship W2072771433A5072485296 @default.
- W2072771433 hasAuthorship W2072771433A5073299652 @default.
- W2072771433 hasAuthorship W2072771433A5076828679 @default.
- W2072771433 hasAuthorship W2072771433A5077210145 @default.