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- W2072774859 abstract "Objective: To perform a case–control study to investigate the association of WNK4 genetic variants with essential hypertension among Beijing residents, and then meta-analyzed all available evidence from current literature. Methods: A total of 688 subjects, including 338 essential hypertension subjects and 350 controls, were recruited from Chinese Multi-provincial Cohort Study (CMCS) in Beijing community for genetic association study. Genotyping was conducted using the homogeneous Mass-EXTEND Assay technique (Sequenom, http://www.sequenom.com). In meta-analysis, case–control reports published in English language and studied on humans were recruited from MEDLINE, EMBASE and Web of Science search engines as of 1 May 2011. Data and study quality were assessed in duplicate. Random-effects model was applied to assess between-studies heterogeneity. Results: Our study identified that variant G1155942T was associated with hypertension risk in Han Chinese. Carriers of the 1155942T allele had an 88% increased risk [odds ratio (OR)=1.88; 95% confidence interval (CI): 1.07–3.31; P=0.029] of developing hypertension and a 2.12-fold increased risk (OR=1.92; 95% CI=1.05–3.49; P=0.022), after controlling for age and sex. Moreover, the strength of this association was potentiated after adjustment for body mass index, smoking, diabetes, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (OR=2.55; 95% CI=1.33–4.88; P=0.005). However, G1156666A provided no evidence for the association with essential hypertension, even under the assumptions of three genetic modes of inheritance (P>0.05). The subsequent meta-analysis included six studies with 2082 cases and 1794 controls. No significant association was attained for both G1155942T and G1156666A variant for hypertension risk in the whole population, even stratified by ethnics (P>0.05). The Egger's test told no publication bias for all associations. Conclusions: Our case–control study and the following meta-analysis collectively demonstrated that WNK4 gene G1155942T variant was associated with essential hypertension in Han Chinese." @default.
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- W2072774859 date "2011-10-01" @default.
- W2072774859 modified "2023-10-16" @default.
- W2072774859 title "Association of the with-no-lysine kinase-4 genetic variants with hypertension risk and blood pressure variation in Han Chinese: A case–control study and meta-analysis" @default.
- W2072774859 doi "https://doi.org/10.1016/j.ijcard.2011.08.632" @default.
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