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• W2072785162 abstract "Matrix metalloproteinase-12 (MMP-12) has been shown to play critical roles in atherogenesis. To determine the cellular mechanisms for control of MMP-12 expression, we studied the effects of several cytokines (GM-CSF, IL-1β, MCP-1) and CD40 ligand on MMP-12 expression in human monocyte/macrophages. Undifferentiated U937 monocytic cells and human peripheral blood monocytes did not express MMP-12. However, in the presence of GM-CSF, these monocytes showed MMP-12 expression at both the transcriptional and protein levels. The combination of treatment with GM-CSF and IL-1β or MCP-1 resulted in a further increase of MMP-12 expression compared to treatment with GM-CSF alone. By contrast, both U937-derived macrophages and human peripheral blood monocyte-derived macrophages showed spontaneous MMP-12 expression, which was significantly increased by the addition of either GM-CSF or anti-CD40Ab. These results indicate that expression of MMP-12 is dependent upon the state of cellular differentiation and enhanced by cytokines and CD40 signaling." @default.
• W2072785162 created "2016-06-24" @default.
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• W2072785162 date "2000-03-01" @default.
• W2072785162 modified "2023-10-16" @default.
• W2072785162 title "Induction and Regulation of Matrix Metalloproteinase-12 by Cytokines and CD40 Signaling in Monocyte/Macrophages" @default.
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• W2072785162 doi "https://doi.org/10.1006/bbrc.2000.2368" @default.
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