FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072785186> ?p ?o ?g. }

• W2072785186 endingPage "180" @default.
• W2072785186 startingPage "165" @default.
• W2072785186 abstract "Extracellular recordings were made from ninety-seven spontaneously firing cells in the paraventricular nucleus (p.v.n.) of the rat hypothalamic slice preparation. The spontaneously firing cells tested fired at 0.1-8 spikes/s but the majority showed a slow irregular firing pattern. The average firing rate of all ninety-seven cells was 2.2 +/- 0.2 spikes/s (mean +/- S.E. of mean). Six cells showed a phasic firing pattern. Following bath application of arginine-vasopressin (AVP) 10(-7) M, sixty-four (66%) of ninety-seven p.v.n. cells showed excitatory responses and three (3%) cells inhibitory responses. Bath application of oxytocin (OXT) 10(-7) M excited thirty-nine (57%) of sixty-eight p.v.n. cells and inhibited two (3%) cells. Individual p.v.n. cells responded to application of both AVP and OXT, but the magnitude and threshold of the responses varied from cell to cell. Of the sixty-six cells tested with both peptides at 10(-7) M, sixteen showed similar responses to both and fifteen showed no response to either: twenty cells showed a greater response to AVP and fifteen a greater response to OXT. Of six phasic firing cells, two showed excitatory responses to AVP and all four cells tested did not show any response to OXT. The dose-dependence of the response to AVP and OXT was tested in six p.v.n. cells. There was a direct relationship between peptide concentration and increased firing rate. The threshold concentration of the peptides ranged from 10(-8) to 10(-10) M. The cells responsive to the peptides were not located in particular areas of the p.v.n. but were diffusely distributed throughout the nucleus. After blocking synaptic transmission with a low Ca2+ and high Mg2+ medium, all tested cells (AVP, n = 15; OXT, n = 14) which had responded to applications of AVP or OXT in normal medium still showed responses to the peptides, although the effect was less marked in half the cells. However, in the absence of synaptic transmission two cells showed unimpaired responses to one of the peptides but greatly depressed responses to the other. The V1-receptor antagonist [1-(beta-mercapto-, beta-cyclopentamethylenepropionic acid)], 8-D-arginine-vasopressin (d(CH2)5DAVP) or V1/V2-receptor antagonist [1-(beta-mercapto-, beta-cyclopentamethylenepropionic acid), 2-D-tyrosine,4-valine]arginine-vasopressin (d(CH2)5D-TyrVAVP) completely or partly blocked the AVP-induced responses, while the V2-receptor agonist 1-deamino-8-D-arginine-vasopressin (dDAVP) did not influence the spontaneous discharges of the cells.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2072785186 created "2016-06-24" @default.
• W2072785186 creator A5020761034 @default.
• W2072785186 creator A5050010393 @default.
• W2072785186 date "1986-01-01" @default.
• W2072785186 modified "2023-09-25" @default.
• W2072785186 title "Excitation of neurones in the rat paraventricular nucleus in vitro by vasopressin and oxytocin." @default.
• W2072785186 cites W1550703169 @default.
• W2072785186 cites W1967100840 @default.
• W2072785186 cites W1968948912 @default.
• W2072785186 cites W1970725646 @default.
• W2072785186 cites W1975239248 @default.
• W2072785186 cites W1997748470 @default.
• W2072785186 cites W2001641971 @default.
• W2072785186 cites W2006017029 @default.
• W2072785186 cites W2011370181 @default.
• W2072785186 cites W2012169215 @default.
• W2072785186 cites W2019223615 @default.
• W2072785186 cites W2028634522 @default.
• W2072785186 cites W2030108220 @default.
• W2072785186 cites W2030167186 @default.
• W2072785186 cites W2035336378 @default.
• W2072785186 cites W2036599728 @default.
• W2072785186 cites W2037051306 @default.
• W2072785186 cites W2042839936 @default.
• W2072785186 cites W2049194182 @default.
• W2072785186 cites W2057380338 @default.
• W2072785186 cites W2063020601 @default.
• W2072785186 cites W2065750409 @default.
• W2072785186 cites W2075522790 @default.
• W2072785186 cites W2086096863 @default.
• W2072785186 cites W2092863206 @default.
• W2072785186 cites W2095470253 @default.
• W2072785186 cites W2129340317 @default.
• W2072785186 cites W2131883705 @default.
• W2072785186 cites W2142529490 @default.
• W2072785186 cites W2414462586 @default.
• W2072785186 cites W2443946626 @default.
• W2072785186 doi "https://doi.org/10.1113/jphysiol.1986.sp015928" @default.
• W2072785186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1192674" @default.
• W2072785186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3007746" @default.
• W2072785186 hasPublicationYear "1986" @default.
• W2072785186 type Work @default.
• W2072785186 sameAs 2072785186 @default.
• W2072785186 citedByCount "135" @default.
• W2072785186 countsByYear W20727851862012 @default.
• W2072785186 countsByYear W20727851862014 @default.
• W2072785186 countsByYear W20727851862015 @default.
• W2072785186 countsByYear W20727851862017 @default.
• W2072785186 countsByYear W20727851862018 @default.
• W2072785186 countsByYear W20727851862019 @default.
• W2072785186 countsByYear W20727851862022 @default.
• W2072785186 crossrefType "journal-article" @default.
• W2072785186 hasAuthorship W2072785186A5020761034 @default.
• W2072785186 hasAuthorship W2072785186A5050010393 @default.
• W2072785186 hasBestOaLocation W20727851861 @default.
• W2072785186 hasConcept C112592302 @default.
• W2072785186 hasConcept C118303440 @default.
• W2072785186 hasConcept C126322002 @default.
• W2072785186 hasConcept C134018914 @default.
• W2072785186 hasConcept C169760540 @default.
• W2072785186 hasConcept C170493617 @default.
• W2072785186 hasConcept C17077164 @default.
• W2072785186 hasConcept C185592680 @default.
• W2072785186 hasConcept C195221683 @default.
• W2072785186 hasConcept C202751555 @default.
• W2072785186 hasConcept C2776176026 @default.
• W2072785186 hasConcept C2776370428 @default.
• W2072785186 hasConcept C2777687476 @default.
• W2072785186 hasConcept C2780723820 @default.
• W2072785186 hasConcept C28406088 @default.
• W2072785186 hasConcept C55493867 @default.
• W2072785186 hasConcept C71924100 @default.
• W2072785186 hasConcept C86803240 @default.
• W2072785186 hasConceptScore W2072785186C112592302 @default.
• W2072785186 hasConceptScore W2072785186C118303440 @default.
• W2072785186 hasConceptScore W2072785186C126322002 @default.
• W2072785186 hasConceptScore W2072785186C134018914 @default.
• W2072785186 hasConceptScore W2072785186C169760540 @default.
• W2072785186 hasConceptScore W2072785186C170493617 @default.
• W2072785186 hasConceptScore W2072785186C17077164 @default.
• W2072785186 hasConceptScore W2072785186C185592680 @default.
• W2072785186 hasConceptScore W2072785186C195221683 @default.
• W2072785186 hasConceptScore W2072785186C202751555 @default.
• W2072785186 hasConceptScore W2072785186C2776176026 @default.
• W2072785186 hasConceptScore W2072785186C2776370428 @default.
• W2072785186 hasConceptScore W2072785186C2777687476 @default.
• W2072785186 hasConceptScore W2072785186C2780723820 @default.
• W2072785186 hasConceptScore W2072785186C28406088 @default.
• W2072785186 hasConceptScore W2072785186C55493867 @default.
• W2072785186 hasConceptScore W2072785186C71924100 @default.
• W2072785186 hasConceptScore W2072785186C86803240 @default.
• W2072785186 hasIssue "1" @default.
• W2072785186 hasLocation W20727851861 @default.
• W2072785186 hasLocation W20727851862 @default.
• W2072785186 hasLocation W20727851863 @default.
• W2072785186 hasOpenAccess W2072785186 @default.
• W2072785186 hasPrimaryLocation W20727851861 @default.

• next