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- W2072788147 abstract "Similar to classical Hodgkin lymphoma (HL) tumour cells, primary effusion lymphoma (PEL) originates from mature B cells but displays a non-B cell phenotype, the mechanisms and consequences of which are not yet understood. This study showed that PEL lacked DNA binding activity of the B cell-determining transcription factors E2A, EBF and Pax5. PEL overexpressed the E2A antagonists ABF-1 and Id2, which have been described to block the B-cell differentiation program in classical HL. However, in contrast to HL cells, B lineage-inappropriate genes were not similarly upregulated in PEL, and reconstitution of B cell-specific E2A homodimer activity in PEL induced apoptosis. These data demonstrate that lineage infidelity in PEL is not as pronounced as in HL, and that the loss of the B cell-specific transcription factor E2A in PEL is implicated in apoptosis protection." @default.
- W2072788147 created "2016-06-24" @default.
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- W2072788147 date "2007-05-01" @default.
- W2072788147 modified "2023-10-18" @default.
- W2072788147 title "Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis" @default.
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- W2072788147 doi "https://doi.org/10.1111/j.1365-2141.2007.06583.x" @default.
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