Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072789518> ?p ?o ?g. }
- W2072789518 endingPage "519" @default.
- W2072789518 startingPage "513" @default.
- W2072789518 abstract "American tegumentary leishmaniasis (ATL) in Peru is mainly associated with Leishmania (Viannia) peruviana and L. (V.) braziliensis. These parasites are genetically related, and their characterization as distinct species is controversial. Despite their genetic similarity, each species is associated with different clinical manifestations of ATL; L. (V.) peruviana causes only cutaneous leishmaniasis, whereas L. (V.) braziliensis can cause both cutaneous and mucocutaneous leishmaniasis. Because the primary cutaneous lesions caused by infection with these species are indistinguishable, it is necessary to develop a suitable method to differentiate them in order to prevent possible metastasis to oropharyngeal mucosa. In the present study, we investigated the proteolytic profile of L. (V.) peruviana and L. (V.) braziliensis isolates from Peru by zymographic analysis in SDS-PAGE copolymerized with gelatin. Enzymes were characterized according to their pH range of activity and sensitivity to distinct peptidase inhibitors. We observed that L. (V.) peruviana isolates displayed three proteolytic bands with molecular masses ranging from 55 to 80 kDa, whereas L. (V.) braziliensis isolates showed six proteolytic activities between 55 and 130 kDa. Using specific inhibitors, we determined that these proteolytic activities are due to metallopeptidases and present optimal activity between the pH range 5.5 and 10.0. Our results suggest that the expression of metallopeptidases in L. (V.) peruviana and L. (V.) braziliensis isolates from Peru is species-specific." @default.
- W2072789518 created "2016-06-24" @default.
- W2072789518 creator A5023866860 @default.
- W2072789518 creator A5028871071 @default.
- W2072789518 creator A5031544051 @default.
- W2072789518 creator A5050987045 @default.
- W2072789518 creator A5052953233 @default.
- W2072789518 creator A5076205040 @default.
- W2072789518 creator A5090746618 @default.
- W2072789518 date "2012-12-01" @default.
- W2072789518 modified "2023-09-27" @default.
- W2072789518 title "Comparative zymographic analysis of metallopeptidase of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis isolates from Peru" @default.
- W2072789518 cites W1565847186 @default.
- W2072789518 cites W1741609474 @default.
- W2072789518 cites W1800392932 @default.
- W2072789518 cites W1855219841 @default.
- W2072789518 cites W1958024510 @default.
- W2072789518 cites W1959117053 @default.
- W2072789518 cites W1963953942 @default.
- W2072789518 cites W1969016211 @default.
- W2072789518 cites W1990402226 @default.
- W2072789518 cites W1999079619 @default.
- W2072789518 cites W2009972285 @default.
- W2072789518 cites W2011236259 @default.
- W2072789518 cites W2012083109 @default.
- W2072789518 cites W2013761931 @default.
- W2072789518 cites W2017801950 @default.
- W2072789518 cites W2019945911 @default.
- W2072789518 cites W2031749092 @default.
- W2072789518 cites W2032153409 @default.
- W2072789518 cites W2034621133 @default.
- W2072789518 cites W2055342557 @default.
- W2072789518 cites W2065656232 @default.
- W2072789518 cites W2065701763 @default.
- W2072789518 cites W2065773854 @default.
- W2072789518 cites W2069341888 @default.
- W2072789518 cites W2071703000 @default.
- W2072789518 cites W2084934898 @default.
- W2072789518 cites W2089330470 @default.
- W2072789518 cites W2090961207 @default.
- W2072789518 cites W2091881012 @default.
- W2072789518 cites W2100726336 @default.
- W2072789518 cites W2105109386 @default.
- W2072789518 cites W2113279589 @default.
- W2072789518 cites W2114413554 @default.
- W2072789518 cites W2138193444 @default.
- W2072789518 cites W2143822687 @default.
- W2072789518 cites W2144833040 @default.
- W2072789518 cites W2157099424 @default.
- W2072789518 cites W2166136713 @default.
- W2072789518 cites W2166668583 @default.
- W2072789518 cites W2168641937 @default.
- W2072789518 cites W2170302951 @default.
- W2072789518 cites W2170956456 @default.
- W2072789518 cites W2283574656 @default.
- W2072789518 cites W2339516286 @default.
- W2072789518 cites W2343754861 @default.
- W2072789518 cites W2414419579 @default.
- W2072789518 cites W2438359601 @default.
- W2072789518 cites W4248396965 @default.
- W2072789518 doi "https://doi.org/10.1016/j.parint.2012.03.007" @default.
- W2072789518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22562004" @default.
- W2072789518 hasPublicationYear "2012" @default.
- W2072789518 type Work @default.
- W2072789518 sameAs 2072789518 @default.
- W2072789518 citedByCount "1" @default.
- W2072789518 countsByYear W20727895182023 @default.
- W2072789518 crossrefType "journal-article" @default.
- W2072789518 hasAuthorship W2072789518A5023866860 @default.
- W2072789518 hasAuthorship W2072789518A5028871071 @default.
- W2072789518 hasAuthorship W2072789518A5031544051 @default.
- W2072789518 hasAuthorship W2072789518A5050987045 @default.
- W2072789518 hasAuthorship W2072789518A5052953233 @default.
- W2072789518 hasAuthorship W2072789518A5076205040 @default.
- W2072789518 hasAuthorship W2072789518A5090746618 @default.
- W2072789518 hasConcept C136764020 @default.
- W2072789518 hasConcept C142724271 @default.
- W2072789518 hasConcept C153911025 @default.
- W2072789518 hasConcept C156662089 @default.
- W2072789518 hasConcept C159047783 @default.
- W2072789518 hasConcept C181199279 @default.
- W2072789518 hasConcept C203014093 @default.
- W2072789518 hasConcept C2776555147 @default.
- W2072789518 hasConcept C2777735729 @default.
- W2072789518 hasConcept C2778702967 @default.
- W2072789518 hasConcept C2779134260 @default.
- W2072789518 hasConcept C2781092759 @default.
- W2072789518 hasConcept C3019223276 @default.
- W2072789518 hasConcept C41008148 @default.
- W2072789518 hasConcept C55493867 @default.
- W2072789518 hasConcept C71924100 @default.
- W2072789518 hasConcept C71928629 @default.
- W2072789518 hasConcept C86803240 @default.
- W2072789518 hasConcept C89423630 @default.
- W2072789518 hasConceptScore W2072789518C136764020 @default.
- W2072789518 hasConceptScore W2072789518C142724271 @default.
- W2072789518 hasConceptScore W2072789518C153911025 @default.
- W2072789518 hasConceptScore W2072789518C156662089 @default.