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• W2072789689 abstract "Enzymatic hydrolysis of nucleotide triphosphate (NTP) plays a pivotal role in protein functions. In spite of its biological significance, however, the chemistry of the hydrolysis catalysis remains obscure because of the complex nature of the reaction. Here we report a study of the molecular mechanism of hydrolysis of adenosine triphosphate (ATP) in F1-ATPase, an ATP-driven rotary motor protein. Molecular simulations predicted and single-molecule observation experiments verified that the rate-determining step (RDS) is proton transfer (PT) from the lytic water molecule, which is strongly activated by a metaphosphate generated by a preceding Pγ–Oβ bond dissociation (POD). Catalysis of the POD that triggers the chain activation of the PT is fulfilled by hydrogen bonds between Walker motif A and an arginine finger, which commonly exist in many NTPases. The reaction mechanism unveiled here indicates that the protein can regulate the enzymatic activity for the function in both the POD and PT steps despite the fact that the RDS is the PT step." @default.
• W2072789689 created "2016-06-24" @default.
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• W2072789689 date "2012-05-11" @default.
• W2072789689 modified "2023-10-16" @default.
• W2072789689 title "Molecular Mechanism of ATP Hydrolysis in F₁-ATPase Revealed by Molecular Simulations and Single-Molecule Observations" @default.
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• W2072789689 doi "https://doi.org/10.1021/ja211027m" @default.
• W2072789689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22548707" @default.
• W2072789689 hasPublicationYear "2012" @default.
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