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• W2072801092 abstract "The present study examined the presence of functional corticotropin-releasing factor (CRF) receptors in IMR-32 neuroblastoma cells. [125I]Tyr°-ovine CRF binding was linear with increasing protein concentrations, saturable, reversible and of high affinity. Scatchard analysis indicated aKd of ∼ 0.8 nM and aBmax of ∼ 32 fmol/mg protein. Competition studies with CRF and related peptides revealed a pharmacological profile characteristic of the CRF1 receptor subtype. CRF stimulated cAMP production in a dose-dependent manner with an apparent EC50 of ∼ 4 nM. In addition, the putative CRF receptor antagonist α-helical CRF9–41 dose-dependently inhibited CRF stimulated (10 nM) cAMP production with an IC50 of ∼ 60 nM. CRF treatment down regulated its own receptor while treatment with the protein kinase C activator, phorbol 12-myristate 13-acetate (PMA), increased CRF binding in neuroblastoma cells. Taken together, these data demonstrate the utility of the human neuroblastoma cell line for functional studies on CRF receptors and suggest that CRF may play a regulatory role in the pathophysiology of human neuroblastoma." @default.
• W2072801092 created "2016-06-24" @default.
• W2072801092 creator A5015600445 @default.
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• W2072801092 date "1996-09-01" @default.
• W2072801092 modified "2023-09-29" @default.
• W2072801092 title "Functional corticotropin-releasing factor receptors in human neuroblastoma cells" @default.
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• W2072801092 doi "https://doi.org/10.1016/0006-8993(96)00752-4" @default.
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