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- W2072801504 abstract "We developed a technique to form a bioabsorbable synthetic polymer (polyglycolic acid, PGA) combined with a natural polymer (fibrin) to serve as a scaffold to help retain seeded cells and improve the seeding efficiency of chondrocytes in an implantable construct. This approach was evaluated in a canine autologous implant model of bioengineered cartilage. The implantation site (subcutaneous or intrafascial) and the use of basic fibroblast growth factor (b-FGF) were also evaluated with this system. The intrafascial implantation site yielded optimal results, especially when used in conjunction with fibrin and a b-FGF sustained-release system incorporated into the complex. A thicker, more sustained cartilagenous layer was formed, with a more vascularized outer fibrous supporting tissue layer. This combined approach of implant environment selection, natural polymer for cell retention, and growth factor supplementation offers a more optimized method for generating bioengineered auricular cartilage." @default.
- W2072801504 created "2016-06-24" @default.
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- W2072801504 date "2012-01-01" @default.
- W2072801504 modified "2023-09-25" @default.
- W2072801504 title "Effect of Local Environment, Fibrin, and Basic Fibroblast Growth Factor Incorporation on a Canine Autologous Model of Bioengineered Cartilage Tissue" @default.
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- W2072801504 doi "https://doi.org/10.1159/000336029" @default.
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