Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072804970> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2072804970 endingPage "376" @default.
- W2072804970 startingPage "368" @default.
- W2072804970 abstract "Subcellular fractions prepared from rat glial cells in culture (clonal line C6) were used in an attempt to characterize the adrenergic receptor involved in adenylate cyclase activation. Both [3H]norepinephrine binding and enzyme activation were measured under identical experimental conditions. Binding sites for norepinephrine could be detected; their main characteristics were: apparent Km : 4 · 10−6 M, maximal capacity: 20 pmol/mg protein. Their stereospecificity towards structually related drugs was found to be different from the stereospecificity of the receptor involved in adenylate cyclase activation. Thus, 3-methoxydopamine (a competitive inhibitor of norepinephrine for adenylate cyclase activation), phenylephrine (a partial adrenergic agonist) and the blocking agent propranolol were unable to compete with [3H]norepinephrine for binding. On the other hand, several molecules like dopa bearing a catechol group and which are unable to interact with the adenylate cyclase as agonists or competitive inhibitors strongly inhibited [3H]norepinephrine binding. As in several other systems so far studied, the presence on the glial cell's membrane of a large number of “catechol-binding sites” makes it difficult to characterize the β-adrenergic receptor." @default.
- W2072804970 created "2016-06-24" @default.
- W2072804970 creator A5034812092 @default.
- W2072804970 creator A5034907668 @default.
- W2072804970 creator A5037111618 @default.
- W2072804970 date "1975-02-01" @default.
- W2072804970 modified "2023-09-27" @default.
- W2072804970 title "[3H]norepinephrine binding by rat glial cells in culture lack of correlation between binding and adenylate cyclase activation" @default.
- W2072804970 cites W113412448 @default.
- W2072804970 cites W1506736401 @default.
- W2072804970 cites W1592059338 @default.
- W2072804970 cites W1609280109 @default.
- W2072804970 cites W1657719861 @default.
- W2072804970 cites W1775749144 @default.
- W2072804970 cites W1985267733 @default.
- W2072804970 cites W1990918868 @default.
- W2072804970 cites W1991175674 @default.
- W2072804970 cites W1993514097 @default.
- W2072804970 cites W2026095561 @default.
- W2072804970 cites W2026912546 @default.
- W2072804970 cites W2064327350 @default.
- W2072804970 cites W2066000944 @default.
- W2072804970 cites W2079067822 @default.
- W2072804970 cites W2095423339 @default.
- W2072804970 cites W2108417705 @default.
- W2072804970 cites W2461572257 @default.
- W2072804970 doi "https://doi.org/10.1016/0304-4165(75)90242-1" @default.
- W2072804970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/163103" @default.
- W2072804970 hasPublicationYear "1975" @default.
- W2072804970 type Work @default.
- W2072804970 sameAs 2072804970 @default.
- W2072804970 citedByCount "8" @default.
- W2072804970 crossrefType "journal-article" @default.
- W2072804970 hasAuthorship W2072804970A5034812092 @default.
- W2072804970 hasAuthorship W2072804970A5034907668 @default.
- W2072804970 hasAuthorship W2072804970A5037111618 @default.
- W2072804970 hasConcept C107824862 @default.
- W2072804970 hasConcept C126322002 @default.
- W2072804970 hasConcept C134018914 @default.
- W2072804970 hasConcept C170493617 @default.
- W2072804970 hasConcept C180526460 @default.
- W2072804970 hasConcept C185592680 @default.
- W2072804970 hasConcept C2778514916 @default.
- W2072804970 hasConcept C2778938600 @default.
- W2072804970 hasConcept C2780069284 @default.
- W2072804970 hasConcept C40465926 @default.
- W2072804970 hasConcept C513476851 @default.
- W2072804970 hasConcept C55493867 @default.
- W2072804970 hasConcept C71924100 @default.
- W2072804970 hasConcept C86803240 @default.
- W2072804970 hasConceptScore W2072804970C107824862 @default.
- W2072804970 hasConceptScore W2072804970C126322002 @default.
- W2072804970 hasConceptScore W2072804970C134018914 @default.
- W2072804970 hasConceptScore W2072804970C170493617 @default.
- W2072804970 hasConceptScore W2072804970C180526460 @default.
- W2072804970 hasConceptScore W2072804970C185592680 @default.
- W2072804970 hasConceptScore W2072804970C2778514916 @default.
- W2072804970 hasConceptScore W2072804970C2778938600 @default.
- W2072804970 hasConceptScore W2072804970C2780069284 @default.
- W2072804970 hasConceptScore W2072804970C40465926 @default.
- W2072804970 hasConceptScore W2072804970C513476851 @default.
- W2072804970 hasConceptScore W2072804970C55493867 @default.
- W2072804970 hasConceptScore W2072804970C71924100 @default.
- W2072804970 hasConceptScore W2072804970C86803240 @default.
- W2072804970 hasIssue "2" @default.
- W2072804970 hasLocation W20728049701 @default.
- W2072804970 hasLocation W20728049702 @default.
- W2072804970 hasOpenAccess W2072804970 @default.
- W2072804970 hasPrimaryLocation W20728049701 @default.
- W2072804970 hasRelatedWork W104979846 @default.
- W2072804970 hasRelatedWork W1977869707 @default.
- W2072804970 hasRelatedWork W1979660518 @default.
- W2072804970 hasRelatedWork W1983321239 @default.
- W2072804970 hasRelatedWork W2002523218 @default.
- W2072804970 hasRelatedWork W2014748341 @default.
- W2072804970 hasRelatedWork W2024545956 @default.
- W2072804970 hasRelatedWork W2156433137 @default.
- W2072804970 hasRelatedWork W2166602181 @default.
- W2072804970 hasRelatedWork W4366741334 @default.
- W2072804970 hasVolume "381" @default.
- W2072804970 isParatext "false" @default.
- W2072804970 isRetracted "false" @default.
- W2072804970 magId "2072804970" @default.
- W2072804970 workType "article" @default.