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• W2072829360 abstract "Diacylglycerol can function as a second messenger, and one mechanism for the attenuation of this signal is its conversion to phosphatidic acid, which is catalyzed by diacylglycerol kinase (DGK). We screened a cDNA library from human skeletal muscle and isolated two DGKzeta cDNAs that differed from the 3.5-kb clone originally identified in endothelial cells. One transcript, which was 3.4 kb long, was shown to be nonfunctional; it had a 77-bp deletion that included the translation initiation site. The other was 4.1 kb long with a unique 5' sequence of 853 bp. We also isolated a genomic clone of DGKzeta and determined its organization and location; it contains 32 exons, spans approximately 50 kb of genomic sequence, and maps to chromosome 11p11.2. The protein encoded by the 4.1-kb transcript contains two cysteine-rich regions, a catalytic domain, and ankyrin repeats like the endothelial form of DGKzeta, as well as a unique N-terminal domain. The coding sequence was shown to be derived from alternative splicing of the DGKzeta gene. In cells transfected with the 4.1-kb clone, we detected a 130-kDa protein with an antibody to DGKzeta and demonstrated that it was localized predominantly in the nucleus. We conclude that alternative splicing generates tissue-specific variants of DGKzeta that share some properties but may have unique ones as well." @default.
• W2072829360 created "2016-06-24" @default.
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• W2072829360 date "1997-05-27" @default.
• W2072829360 modified "2023-10-14" @default.
• W2072829360 title "Alternative splicing of the human diacylglycerol kinase ζ gene in muscle" @default.
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• W2072829360 doi "https://doi.org/10.1073/pnas.94.11.5519" @default.
• W2072829360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/20810" @default.
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