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- W2072829752 abstract "The anesthetised pig excreted acidic metabolites of progesterone in the bile and urine. Liver microsomes hydroxylated progesterone at the C-21, 6β- and 16α-position and were inhibited by Ketoconazole. The pig exhibited intraspecies variability in progesterone 21- and 6β-hydroxylases. Liver, adrenal and to a lesser extent kidney microsomes oxidised the α-ketol side-chain to a C-21-oic acid. The liver reaction gave high affinity, low Km kinetics and a Vmax of 28.6 pmol acids min−1 mg microsomal protein−1. Both carbon monoxide and Ketoconazole were inhibitory. These results implicate the cytochrome P-450 system with the ring and side-chain oxidations of progesterone. The pig resembled the rabbit in its metabolism of progesterone and is the second species in which a microsomal α-ketol oxidase has been implicated in the biosynthesis of steroidal acids." @default.
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- W2072829752 date "1988-08-01" @default.
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- W2072829752 title "Progesterone hydroxylation and side chain oxidation to acidic metabolites by the pig" @default.
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- W2072829752 doi "https://doi.org/10.1016/0022-4731(88)90057-x" @default.
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