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- W2072831081 abstract "1. This study was designed to examine the influence of glucose consumption on induction of tyrosine aminotransferase (EC 2.6.1.5) and tryptophan oxygenase (EC 1.11.1.4) by glucocorticoids, trytophan and casein. 2. Glucose feeding lowers basals levels of these enzymes and the magnitude of the rise in levels after inducer. The ratio between induced and basal enzymes and the magnitude was essentially unaffected. Glucose treatment did not simply delay induction of these enzymes by inducer but rather depressed enzyme levels throughout the period of enzyme induction. 3. In adrenalectomized animals, glucose pretreatment lower the induction of these enzymes by casein but not by tryptopha. 4. These and other observations lead us to suggest that tryptophan oxygenase functions to regulate intracellular tryptophan levels and that tryptophan levels play a key role in shifting metabolism between protein synthesis and gluconeogenesis." @default.
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- W2072831081 date "1970-06-01" @default.
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- W2072831081 title "Alterations in induction of tyrosine aminotransferase and tryptophan oxygenase by glucose pretreatment" @default.
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- W2072831081 doi "https://doi.org/10.1016/0304-4165(70)90215-1" @default.
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