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- W2072847038 abstract "Programmed cell death (PCD) is an ordered and tightly controlled set of changes in gene expression and protein activity that results in neuronal cell death during brain development. This article reviews the molecular pathways by which PCD is executed in mammalian cells and the potential relation of these pathways to pathologic neuronal cell death. Whereas the classical patterns of apoptotic morphologic change often do not appear in the brain after ischemia, there is emerging biochemical and pharmacologic evidence suggesting a role for PCD in ischemic brain injury. The most convincing evidence for the induction of PCD after ischemia includes the altered expression and activity in the ischemic brain of deduced key death-regulatory genes. Furthermore, studies have shown that alterations in the activity of these gene products by peptide inhibitors, viral vector-mediated gene transfer, antisense oligonucleotides, or transgenic mouse techniques determine, at least in part, whether ischemic neurons live or die after stroke. These studies provide strong support for the hypothesis that PCD contributes to neuronal cell death caused by ischemic injury. However, many questions remain regarding the precise pathways that initiate, sense, and transmit cell death signals in ischemic neurons and the molecular mechanisms by which neuronal cell death is executed at different stages of ischemic injury. Elucidation of these pathways and mechanisms may lead to the development of novel therapeutic strategies for brain injury after stroke and related neurologic disorders." @default.
- W2072847038 created "2016-06-24" @default.
- W2072847038 creator A5024089474 @default.
- W2072847038 creator A5088275272 @default.
- W2072847038 date "2001-02-01" @default.
- W2072847038 modified "2023-09-25" @default.
- W2072847038 title "Programmed Cell Death in Cerebral Ischemia" @default.
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- W2072847038 cites W1529927626 @default.
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- W2072847038 cites W1591022300 @default.
- W2072847038 cites W1593219141 @default.
- W2072847038 cites W1613986623 @default.
- W2072847038 cites W1845459216 @default.
- W2072847038 cites W1904882776 @default.
- W2072847038 cites W1924646174 @default.
- W2072847038 cites W1963764076 @default.
- W2072847038 cites W1965924957 @default.
- W2072847038 cites W1971335269 @default.
- W2072847038 cites W1973109581 @default.
- W2072847038 cites W1975896299 @default.
- W2072847038 cites W1976312800 @default.
- W2072847038 cites W1976467696 @default.
- W2072847038 cites W1982687089 @default.
- W2072847038 cites W1983112915 @default.
- W2072847038 cites W1984431818 @default.
- W2072847038 cites W1985923619 @default.
- W2072847038 cites W1987766146 @default.
- W2072847038 cites W1988171628 @default.
- W2072847038 cites W1988355439 @default.
- W2072847038 cites W1994081180 @default.
- W2072847038 cites W1999836223 @default.
- W2072847038 cites W2001110380 @default.
- W2072847038 cites W2004568898 @default.
- W2072847038 cites W2006625418 @default.
- W2072847038 cites W2008035030 @default.
- W2072847038 cites W2013319326 @default.
- W2072847038 cites W2013877892 @default.
- W2072847038 cites W2016640140 @default.
- W2072847038 cites W2029479814 @default.
- W2072847038 cites W2033828028 @default.
- W2072847038 cites W2034528524 @default.
- W2072847038 cites W2036885170 @default.
- W2072847038 cites W2038813809 @default.
- W2072847038 cites W2039515131 @default.
- W2072847038 cites W2040053768 @default.
- W2072847038 cites W2046170990 @default.
- W2072847038 cites W2048333479 @default.
- W2072847038 cites W2053200671 @default.
- W2072847038 cites W2057638542 @default.
- W2072847038 cites W2058591356 @default.
- W2072847038 cites W2059006262 @default.
- W2072847038 cites W2059666350 @default.
- W2072847038 cites W2061497413 @default.
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- W2072847038 cites W2076841455 @default.
- W2072847038 cites W2078581194 @default.
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- W2072847038 cites W2080346297 @default.
- W2072847038 cites W2083271570 @default.
- W2072847038 cites W2083560313 @default.
- W2072847038 cites W2088270787 @default.
- W2072847038 cites W2089984162 @default.
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- W2072847038 cites W2133726754 @default.
- W2072847038 cites W2134979684 @default.
- W2072847038 cites W2136308095 @default.
- W2072847038 cites W2136781825 @default.
- W2072847038 cites W2139410513 @default.
- W2072847038 cites W2143772496 @default.
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- W2072847038 cites W2147122201 @default.
- W2072847038 cites W2151501496 @default.
- W2072847038 cites W2154979711 @default.
- W2072847038 cites W2157645771 @default.
- W2072847038 cites W2157888986 @default.
- W2072847038 cites W2158799442 @default.
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- W2072847038 cites W2164169192 @default.
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- W2072847038 doi "https://doi.org/10.1097/00004647-200102000-00001" @default.
- W2072847038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11176275" @default.
- W2072847038 hasPublicationYear "2001" @default.
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