FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072860557> ?p ?o ?g. }

• W2072860557 abstract "1. The neuronal effects of the anthelmintic piperazine (Pip) on rat sympathetic ganglia were studied in vitro by means of intracellular and extracellular recording techniques. 2. Surface potential recordings indicated that Pip (0.1-10 mM as citrate, 1-30 mM as hexahydrate) produced a sustained depolarization (reversible on washing) of rat ganglia. gamma-Aminobutyric acid (GABA, 1-100 micro M) also evoked reversible depolarizations but, unlike Pip, responses to the higher doses of GABA declined during a 2 min exposure. Depolarizations produced by Pip or carbachol (but not GABA) were markedly depressed by hexamethonium but only slightly by bicuculline or picrotoxin. 3. Intracellular recordings revealed that Pip-induced depolarizations were accompanied by an increase in membrane conductance and a broadening and depression of the directly-evoked spike. 4. In the presence of hexamethonium (1 mM), the responses to Pip hexahydrate and to cholinoceptor agonists were abolished, but Pip citrate still changed the spike configuration and induced membrane hyperpolarization with a small conductance increase. These residual effects were mimicked by superfusing with Na citrate or Ca2+-free medium, suggesting that significant Ca2+ binding by the citrate anion of the Pip salt was probably responsible for the observed activity of Pip citrate in the presence of hexamethonium. 5. It is concluded that on rat ganglia Pip is a nicotinic agonist, with no detectable GABA-mimetic activity." @default.
• W2072860557 created "2016-06-24" @default.
• W2072860557 creator A5010367078 @default.
• W2072860557 creator A5042838362 @default.
• W2072860557 creator A5056423631 @default.
• W2072860557 creator A5069367267 @default.
• W2072860557 creator A5085409739 @default.
• W2072860557 date "1981-10-01" @default.
• W2072860557 modified "2023-09-27" @default.
• W2072860557 title "THE EFFECTS OF PIPERAZINE ON RAT SYMPATHETIC NEURONES" @default.
• W2072860557 cites W131408370 @default.
• W2072860557 cites W1964813603 @default.
• W2072860557 cites W1972976854 @default.
• W2072860557 cites W1996066806 @default.
• W2072860557 cites W1998845175 @default.
• W2072860557 cites W2002165966 @default.
• W2072860557 cites W2003937578 @default.
• W2072860557 cites W2011788359 @default.
• W2072860557 cites W2019256742 @default.
• W2072860557 cites W2021432550 @default.
• W2072860557 cites W2024835184 @default.
• W2072860557 cites W2024905996 @default.
• W2072860557 cites W2028274352 @default.
• W2072860557 cites W2028387670 @default.
• W2072860557 cites W2039005332 @default.
• W2072860557 cites W2040934669 @default.
• W2072860557 cites W2048491861 @default.
• W2072860557 cites W2070722619 @default.
• W2072860557 cites W2072130450 @default.
• W2072860557 cites W2072209071 @default.
• W2072860557 cites W2073247537 @default.
• W2072860557 cites W2081301520 @default.
• W2072860557 cites W2090510623 @default.
• W2072860557 cites W2153232010 @default.
• W2072860557 cites W2342357636 @default.
• W2072860557 cites W2416453083 @default.
• W2072860557 cites W2424261606 @default.
• W2072860557 cites W2443584728 @default.
• W2072860557 cites W2469639416 @default.
• W2072860557 cites W4229541825 @default.
• W2072860557 cites W4234726131 @default.
• W2072860557 cites W1984364389 @default.
• W2072860557 doi "https://doi.org/10.1111/j.1476-5381.1981.tb09990.x" @default.
• W2072860557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2071726" @default.
• W2072860557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7317692" @default.
• W2072860557 hasPublicationYear "1981" @default.
• W2072860557 type Work @default.
• W2072860557 sameAs 2072860557 @default.
• W2072860557 citedByCount "7" @default.
• W2072860557 crossrefType "journal-article" @default.
• W2072860557 hasAuthorship W2072860557A5010367078 @default.
• W2072860557 hasAuthorship W2072860557A5042838362 @default.
• W2072860557 hasAuthorship W2072860557A5056423631 @default.
• W2072860557 hasAuthorship W2072860557A5069367267 @default.
• W2072860557 hasAuthorship W2072860557A5085409739 @default.
• W2072860557 hasBestOaLocation W20728605572 @default.
• W2072860557 hasConcept C12554922 @default.
• W2072860557 hasConcept C126322002 @default.
• W2072860557 hasConcept C131453863 @default.
• W2072860557 hasConcept C134018914 @default.
• W2072860557 hasConcept C147944092 @default.
• W2072860557 hasConcept C168258287 @default.
• W2072860557 hasConcept C168481208 @default.
• W2072860557 hasConcept C170493617 @default.
• W2072860557 hasConcept C181911157 @default.
• W2072860557 hasConcept C185592680 @default.
• W2072860557 hasConcept C2775893369 @default.
• W2072860557 hasConcept C2778071365 @default.
• W2072860557 hasConcept C2778988552 @default.
• W2072860557 hasConcept C2779324764 @default.
• W2072860557 hasConcept C2780763569 @default.
• W2072860557 hasConcept C4141045 @default.
• W2072860557 hasConcept C55493867 @default.
• W2072860557 hasConcept C66974803 @default.
• W2072860557 hasConcept C71240020 @default.
• W2072860557 hasConcept C71924100 @default.
• W2072860557 hasConcept C86803240 @default.
• W2072860557 hasConceptScore W2072860557C12554922 @default.
• W2072860557 hasConceptScore W2072860557C126322002 @default.
• W2072860557 hasConceptScore W2072860557C131453863 @default.
• W2072860557 hasConceptScore W2072860557C134018914 @default.
• W2072860557 hasConceptScore W2072860557C147944092 @default.
• W2072860557 hasConceptScore W2072860557C168258287 @default.
• W2072860557 hasConceptScore W2072860557C168481208 @default.
• W2072860557 hasConceptScore W2072860557C170493617 @default.
• W2072860557 hasConceptScore W2072860557C181911157 @default.
• W2072860557 hasConceptScore W2072860557C185592680 @default.
• W2072860557 hasConceptScore W2072860557C2775893369 @default.
• W2072860557 hasConceptScore W2072860557C2778071365 @default.
• W2072860557 hasConceptScore W2072860557C2778988552 @default.
• W2072860557 hasConceptScore W2072860557C2779324764 @default.
• W2072860557 hasConceptScore W2072860557C2780763569 @default.
• W2072860557 hasConceptScore W2072860557C4141045 @default.
• W2072860557 hasConceptScore W2072860557C55493867 @default.
• W2072860557 hasConceptScore W2072860557C66974803 @default.
• W2072860557 hasConceptScore W2072860557C71240020 @default.
• W2072860557 hasConceptScore W2072860557C71924100 @default.
• W2072860557 hasConceptScore W2072860557C86803240 @default.
• W2072860557 hasLocation W20728605571 @default.
• W2072860557 hasLocation W20728605572 @default.

• next