FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072865691> ?p ?o ?g. }

• W2072865691 endingPage "4207" @default.
• W2072865691 startingPage "4195" @default.
• W2072865691 abstract "Human immunodeficiency virus (HIV)-specific helper T lymphocytes (HTL) play a key role in the immune control of HIV type 1 (HIV-1) infection, and as such are an important target of potential HIV-1 vaccines. In order to identify HTL epitopes in HIV-1 that might serve as vaccine targets, conserved HIV-1-derived peptides bearing an HLA-DR binding supermotif were tested for binding to a panel of the most representative HLA-DR molecules. Eleven highly cross-reactive binding peptides were identified: three in Gag and eight in Pol. Lymphoproliferative responses to this panel of peptides, as well as to the HIV-1 p24 and p66 proteins, were evaluated with a cohort of 31 HIV-1-infected patients. All 11 peptides were recognized by peripheral blood mononuclear cells from multiple HIV-infected donors. Many of the responsive HIV-infected subjects showed recognition of multiple peptides, indicating that HIV-1-specific T-helper responses may be broadly directed in certain individuals. A strong association existed between recognition of the parental recombinant HIV-1 protein and the corresponding HTL peptides, suggesting that these peptides represent epitopes that are processed and presented during the course of HIV-1 infection. Lastly, responses to the supermotif peptides were mediated by CD4(+) T cells and were restricted by major histocompatibility complex class II molecules. The epitopes described herein are potentially important components of HIV-1 therapeutic and prophylactic vaccines." @default.
• W2072865691 created "2016-06-24" @default.
• W2072865691 creator A5010966529 @default.
• W2072865691 creator A5031752691 @default.
• W2072865691 creator A5036354240 @default.
• W2072865691 creator A5037285448 @default.
• W2072865691 creator A5041720192 @default.
• W2072865691 creator A5056006726 @default.
• W2072865691 creator A5062001150 @default.
• W2072865691 creator A5071318619 @default.
• W2072865691 creator A5083401692 @default.
• W2072865691 date "2001-05-01" @default.
• W2072865691 modified "2023-09-29" @default.
• W2072865691 title "Identification and Antigenicity of Broadly Cross-Reactive and Conserved Human Immunodeficiency Virus Type 1-Derived Helper T-Lymphocyte Epitopes" @default.
• W2072865691 cites W1503151765 @default.
• W2072865691 cites W1523485804 @default.
• W2072865691 cites W1531831170 @default.
• W2072865691 cites W1574561647 @default.
• W2072865691 cites W1588864421 @default.
• W2072865691 cites W1675195038 @default.
• W2072865691 cites W1944657476 @default.
• W2072865691 cites W1956173684 @default.
• W2072865691 cites W1963958510 @default.
• W2072865691 cites W1971203392 @default.
• W2072865691 cites W1972103487 @default.
• W2072865691 cites W1973539060 @default.
• W2072865691 cites W1974647588 @default.
• W2072865691 cites W1977590978 @default.
• W2072865691 cites W1982448824 @default.
• W2072865691 cites W1982752226 @default.
• W2072865691 cites W1984813611 @default.
• W2072865691 cites W1991255132 @default.
• W2072865691 cites W1996609637 @default.
• W2072865691 cites W2009881953 @default.
• W2072865691 cites W2031046131 @default.
• W2072865691 cites W2031477951 @default.
• W2072865691 cites W2033431358 @default.
• W2072865691 cites W2033669010 @default.
• W2072865691 cites W2035705701 @default.
• W2072865691 cites W2037343680 @default.
• W2072865691 cites W2048999843 @default.
• W2072865691 cites W2053600139 @default.
• W2072865691 cites W2068941010 @default.
• W2072865691 cites W2079176471 @default.
• W2072865691 cites W2085114777 @default.
• W2072865691 cites W2085919513 @default.
• W2072865691 cites W2087259832 @default.
• W2072865691 cites W2109000128 @default.
• W2072865691 cites W2118148901 @default.
• W2072865691 cites W2121956497 @default.
• W2072865691 cites W2125586839 @default.
• W2072865691 cites W2126375281 @default.
• W2072865691 cites W2129672006 @default.
• W2072865691 cites W2143329914 @default.
• W2072865691 cites W2149754518 @default.
• W2072865691 cites W2154218796 @default.
• W2072865691 cites W2163840176 @default.
• W2072865691 cites W2166730310 @default.
• W2072865691 cites W2167174534 @default.
• W2072865691 cites W2170219825 @default.
• W2072865691 cites W2319302088 @default.
• W2072865691 cites W2414847699 @default.
• W2072865691 cites W304288403 @default.
• W2072865691 cites W86687369 @default.
• W2072865691 doi "https://doi.org/10.1128/jvi.75.9.4195-4207.2001" @default.
• W2072865691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114165" @default.
• W2072865691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11287569" @default.
• W2072865691 hasPublicationYear "2001" @default.
• W2072865691 type Work @default.
• W2072865691 sameAs 2072865691 @default.
• W2072865691 citedByCount "102" @default.
• W2072865691 countsByYear W20728656912012 @default.
• W2072865691 countsByYear W20728656912013 @default.
• W2072865691 countsByYear W20728656912014 @default.
• W2072865691 countsByYear W20728656912015 @default.
• W2072865691 countsByYear W20728656912016 @default.
• W2072865691 countsByYear W20728656912017 @default.
• W2072865691 countsByYear W20728656912018 @default.
• W2072865691 countsByYear W20728656912019 @default.
• W2072865691 countsByYear W20728656912020 @default.
• W2072865691 countsByYear W20728656912021 @default.
• W2072865691 countsByYear W20728656912022 @default.
• W2072865691 countsByYear W20728656912023 @default.
• W2072865691 crossrefType "journal-article" @default.
• W2072865691 hasAuthorship W2072865691A5010966529 @default.
• W2072865691 hasAuthorship W2072865691A5031752691 @default.
• W2072865691 hasAuthorship W2072865691A5036354240 @default.
• W2072865691 hasAuthorship W2072865691A5037285448 @default.
• W2072865691 hasAuthorship W2072865691A5041720192 @default.
• W2072865691 hasAuthorship W2072865691A5056006726 @default.
• W2072865691 hasAuthorship W2072865691A5062001150 @default.
• W2072865691 hasAuthorship W2072865691A5071318619 @default.
• W2072865691 hasAuthorship W2072865691A5083401692 @default.
• W2072865691 hasBestOaLocation W20728656912 @default.
• W2072865691 hasConcept C147483822 @default.
• W2072865691 hasConcept C159047783 @default.
• W2072865691 hasConcept C159654299 @default.
• W2072865691 hasConcept C188280979 @default.

• next