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- W2072865728 abstract "In control rats and in rats after intraventricular injection of 6-hydroxydopamine, the total specific binding of [3H]dihydroergokryptine to membranes of the cerebral cortex was studied. The time course of the catecholaminergic denervation in its influence on total α-adrenoceptors, and on the binding to α1-receptors was followed, after blocking the α2, with yohimbine. Using displacement curves, 5 × 10−7 M was determined as the concentration of yohimbine needed to differentiate α1 from α2-adrenoceptors. In control rats, the total binding showed a Bmax of 300 pmol/g protein and a KD of 1.9 nM with a single type of binding site. The binding of [3H]dihydroergokryptine that was not displaced by yohimbine represented about 70% of the total. Denervation by 6-hydroxydopamine produced, after two days, a decrease in total binding (P < 0.01), followed by a progressive increase, that reached 41% above the control after 22 days (P < 0.1). The α1-sites were reduced after two days and later increased to reach 63% above the control (P < 0.01) at 22 days. These results suggest that after catecholaminergic denervation there is an increase in total α-adrenoceptors and in α1-receptors in membranes of the cerebral cortex. These changes could be correlated with a possible post-synaptic supersensitivity after denervation." @default.
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- W2072865728 date "1984-07-01" @default.
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- W2072865728 title "Time-course in binding of 63H9dihydroergokryptine to total alpha and alpha1 adrenoceptors of cerebral cortex of rat after denervation by 6-hydroxydopamine" @default.
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- W2072865728 doi "https://doi.org/10.1016/0028-3908(84)90116-3" @default.
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