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• W2072878440 endingPage "e85981" @default.
• W2072878440 startingPage "e85981" @default.
• W2072878440 abstract "Investigating the interactions between nanoscale materials and microorganisms is crucial to provide a comprehensive, proactive understanding of nanomaterial toxicity and explore the potential for novel applications. It is well known that nanomaterial behavior is governed by the size and composition of the particles, though the effects of small differences in size toward biological cells have not been well investigated. Palladium nanoparticles (Pd NPs) have gained significant interest as catalysts for important carbon-carbon and carbon-heteroatom reactions and are increasingly used in the chemical industry, however, few other applications of Pd NPs have been investigated. In the present study, we examined the antimicrobial capacity of Pd NPs, which provides both an indication of their usefulness as target antimicrobial compounds, as well as their potency as potential environmental pollutants. We synthesized Pd NPs of three different well-constrained sizes, 2.0±0.1 nm, 2.5±0.2 nm and 3.1±0.2 nm. We examined the inhibitory effects of the Pd NPs and Pd2+ ions toward gram negative Escherichia coli (E. coli) and gram positive Staphylococcus aureus (S. aureus) bacterial cultures throughout a 24 hour period. Inhibitory growth effects of six concentrations of Pd NPs and Pd2+ ions (2.5×10−4, 10−5, 10−6, 10−7, 10−8, and 10−9 M) were examined. Our results indicate that Pd NPs are generally much more inhibitory toward S. aureus than toward E. coli, though all sizes are toxic at ≥10−5 M to both organisms. We observed a significant difference in size-dependence of antimicrobial activity, which differed based on the microorganism tested. Our work shows that Pd NPs are highly antimicrobial, and that fine-scale (<1 nm) differences in size can alter antimicrobial activity." @default.
• W2072878440 created "2016-06-24" @default.
• W2072878440 creator A5032853576 @default.
• W2072878440 creator A5040320437 @default.
• W2072878440 creator A5063772932 @default.
• W2072878440 creator A5086454553 @default.
• W2072878440 date "2014-01-20" @default.
• W2072878440 modified "2023-09-23" @default.
• W2072878440 title "Size-Dependent Antimicrobial Effects of Novel Palladium Nanoparticles" @default.
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• W2072878440 doi "https://doi.org/10.1371/journal.pone.0085981" @default.
• W2072878440 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3896427" @default.
• W2072878440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24465824" @default.

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