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- W2072879149 abstract "Mitochondria were isolated from the posterior region of the midgut of the tobacco hornworm, Manduca sexta. Measurements of mitochondrial oxygen consumption revealed that the oxidation of palmitoyl carnitine plus malate was inhibited by 3-mercaptopropionic acid (MPA) in a dose-dependent manner. The maximal percent inhibition was 65% and the I50 was 0.15mM. When exposed to a dose which maximally inhibits the oxidation of palmitoyl carnitine (0.5 mM), mitochondrial oxidation of octanoate and pyruvate were inhibited by 30 and 8%, respectively. Oxidation of succinate was unaffected under these conditions. These results indicate that MPA is an effective inhibitor of fatty acid oxidation in midgut mitochondria." @default.
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- W2072879149 date "1989-01-01" @default.
- W2072879149 modified "2023-09-26" @default.
- W2072879149 title "Inhibition of palmitoyl carnitine oxidation by 3-mercaptopropionic acid in mitochondria isolated from tobacco hornworm (Manduca sexta) midgut" @default.
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- W2072879149 doi "https://doi.org/10.1016/0020-1790(89)90070-x" @default.
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