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• W2072883404 abstract "Central nervous system (CNS) astrocytes release guanosine extracellularly, that exerts trophic effects. In CNS, extracellular guanosine (GUO) stimulates mitosis, synthesis of trophic factors, and cell differentiation, including neuritogenesis, is neuroprotective, and reduces apoptosis due to several stimuli. Specific receptor-like binding sites for eGUO in the nervous system may mediate its effects through both MAP kinase and PI3-kinase signalling pathways. Extracellular guanine (eGUA) also exerts several effects; the trophic effects of eGUO are likely regulated by conversion of eGUO to eGUA by a membrane located purine nucleoside phosphorylase (ecto-PNP) and by conversion of eGUA to xanthine by guanine deaminase." @default.
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• W2072883404 date "2008-07-23" @default.
• W2072883404 modified "2023-09-23" @default.
• W2072883404 title "Neurotrophic Effects of Extracellular Guanosine" @default.
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• W2072883404 doi "https://doi.org/10.1080/15257770802143913" @default.
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