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- W2072895366 abstract "Nanopores of both protein and solid-state composition provide an excellent tool for single molecule sensing, particularly for DNA. Nanopores are nanometer-sized holes that provide the only pathway between two ionic baths. DNA is sensed by electrophoretically driving it into the nanopore which temporarily causes a reduction in ionic current as the DNA translocates. The protein nanopore Mycobacteria smegmatis porin A (MspA) has a geometry enabling the discrimination of the four nucleotides using ssDNA. This discrimination is easily observed when ssDNA translocation is briefly interrupted by complimentary oligonucleotides which must dissociate before ssDNA translocation can occur. We show that such duplex-interrupted translocation yields the ability to sense nucleotide composition on various strands of DNA. Such sensing could be useful in next-generation sequencing techniques with nanopores." @default.
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- W2072895366 date "2010-01-01" @default.
- W2072895366 modified "2023-09-30" @default.
- W2072895366 title "A Novel DNA Sensing Technique using the Nanopore MspA" @default.
- W2072895366 doi "https://doi.org/10.1016/j.bpj.2009.12.2286" @default.
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