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- W2072896627 abstract "A rapid, sensitive assay for angiotensin-converting enzyme (ACE) inhibitors is described. Biological samples were diluted with methanol to precipitate endogenous ACE and centrifuged. Supernatants were further diluted with 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid buffer, pH 8. Diluted samples were incubated at 37°C with the substrate [3H]hippurylglycylglycine and rabbit lung ACE for 45 min. Acid (1.0 n HCl) was then added, and the product, [3H]hippuric acid, was extracted into a water-immiscible scintillation cocktail. Drug standards were prepared in the biological matrix to correct for drug recovery. A computer program was used to convert radioactivity (dpm) to units of enzyme activity and then correlate enzyme activity with drug concentration. The ester prodrugs fosenopril and enalapril could be assayed down to 4 ng/ml in plasma after ester hydrolysis with NaOH. Drug disposition studies in rats, dogs, and monkeys have demonstrated that the method can be readily adapted to any ACE inhibitor and is suitable for determining drug bioavailability and pharmacokinetics." @default.
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- W2072896627 date "1985-08-01" @default.
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- W2072896627 title "Radioenzymatic assay of angiotensin-converting enzyme inhibitors in plasma and urine" @default.
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- W2072896627 doi "https://doi.org/10.1016/0003-2697(85)90245-3" @default.
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