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- W2072898272 abstract "A pharmacological analysis was carried out of the responses of guinea-pig isolated terminal colon to transmural, parasyinpathetic and sympathetic electrical stimulation. The contraction produced by stimulating the pelvic nerves was abolished by atropine and the inhibition produced by stimulating the periarterial nerves was suppressed by dibenamine plus propranolol and by adrenergic blocking agents. After complete pharmacological blockade of extrinsic sympathetic and parasympathetic supply, transmural stimulation produced a pure inhibitory response particularly when low frequencies (1–2/sec) were used. This response was abolished by tetrodotoxin. Some physiologically occurring substances were tested with the aim of mimicking such inhibition, but this was unsuccessful. 5-Hydroxy-tryptamine displayed complex effects, mediated through the intramural nervous structures; moreover it evoked a non-adrenergic inhibitory response which was abolished by tetrodotoxin. The presence of non-adrenergic inhibitory structures was confirmed in this part of the gastrointestinal tract. The possible nature of the contractile response which follows the primary inhibition due to transmural stimulation is discussed. It is suggested that the possible release of excitatory and inhibitory substances, different from the so-called “neurotransmitters”, is a consequence of physical and chemical stimulation of the intestinal wall." @default.
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- W2072898272 date "1968-08-01" @default.
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- W2072898272 title "Further evidence for the presence of non-adrenergic inhibitory structures in the guinea-pig colon" @default.
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- W2072898272 doi "https://doi.org/10.1016/0014-2999(68)90009-5" @default.
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